The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cysteine Rich Protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: LIM domain-containing protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 A6NIX2 (/IPI) Q06BR1 (/IPI) Q7TQJ8 (/IPI) Q91XC0 (/IPI) Q96IF1 (/IPI) Q96IF1 (/IPI) Q96IF1 (/IPI) Q96IF1 (/IPI) Q9QXD8 (/IPI) Q9UGP4 (/IPI)
(1 more)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
8 A8DZE6 (/ISS) B5DEH0 (/ISS) B7ZUL2 (/ISS) E1BKA3 (/ISS) E1BKA3 (/ISS) G5E5X0 (/ISS) Q5U2Z2 (/ISS) Q9UGP4 (/ISS)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
7 Q7TQJ8 (/IDA) Q91XC0 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q9QXD8 (/IDA)
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
5 Q91XC0 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
3 A9LS46 (/IMP) Q06BR1 (/IMP) Q91XC0 (/IMP)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q91XC0 (/IDA)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
1 Q91XC0 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9UGP4 (/TAS)
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
1 Q91XC0 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q91XC0 (/IDA)
Showing 1 to 10 of 10 entries

There are 80 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Negative regulation of hippo signaling GO:0035331
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
8 B5DEH0 (/ISS) E1BKA3 (/ISS) E1BKA3 (/ISS) G5E5X0 (/ISS) Q5U2Z2 (/ISS) Q7TQJ8 (/ISS) Q91XC0 (/ISS) Q9QXD8 (/ISS)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
8 B5DEH0 (/ISS) E1BKA3 (/ISS) E1BKA3 (/ISS) G5E5X0 (/ISS) Q5U2Z2 (/ISS) Q7TQJ8 (/ISS) Q91XC0 (/ISS) Q9QXD8 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
6 A6NIX2 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q9UGP4 (/IDA)
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
6 A6NIX2 (/IMP) Q96IF1 (/IMP) Q96IF1 (/IMP) Q96IF1 (/IMP) Q96IF1 (/IMP) Q9UGP4 (/IMP)
Negative regulation of hippo signaling GO:0035331
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
6 A6NIX2 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q9UGP4 (/IDA)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
6 A6NIX2 (/IMP) Q96IF1 (/IMP) Q96IF1 (/IMP) Q96IF1 (/IMP) Q96IF1 (/IMP) Q9UGP4 (/IMP)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
4 Q96IF1 (/TAS) Q96IF1 (/TAS) Q96IF1 (/TAS) Q96IF1 (/TAS)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
4 A8DZE6 (/ISS) A9LS46 (/ISS) Q7TQJ8 (/ISS) Q9QXD8 (/ISS)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
4 Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA)
Regulation of cellular response to hypoxia GO:1900037
Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
4 Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA)
Showing 1 to 10 of 80 entries

There are 32 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 C9JRJ5 (/IDA) Q91XC0 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q9UGP4 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
6 A6NIX2 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q9UGP4 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
6 Q5U2Z2 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q9VY77 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
5 E1BKA3 (/ISS) E1BKA3 (/ISS) Q5U2Z2 (/ISS) Q7TQJ8 (/ISS) Q91XC0 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q91XC0 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q96IF1 (/TAS) Q96IF1 (/TAS) Q96IF1 (/TAS) Q96IF1 (/TAS) Q9UGP4 (/TAS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA) Q96IF1 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
3 Q7TQJ8 (/ISO) Q91XC0 (/ISO) Q9QXD8 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 B5DEH0 (/ISS) G5E5X0 (/ISS) Q9QXD8 (/ISS)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
3 B5DEH0 (/ISS) G5E5X0 (/ISS) Q9QXD8 (/ISS)
Showing 1 to 10 of 32 entries
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