CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P23458
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P23458
JAK1_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK1

PDB Structure

PDB 6N79
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Zak, M., Hanan, E.J., Lupardus, P., Brown, D.G., Robinson, C., Siu, M., Lyssikatos, J.P., Romero, F.A., Zhao, G., Kellar, T., Mendonca, R., Ray, N.C., Goodacre, S.C., Crackett, P.H., McLean, N., Hurley, C.A., Yuen, P.W., Cheng, Y.X., Liu, X., Liimatta, M., Kohli, P.B., Nonomiya, J., Salmon, G., Buckley, G., Lloyd, J., Gibbons, P., Ghilardi, N., Kenny, J.R., Johnson, A.
Bioorg.Med.Chem.Lett.
CATH-Gene3D is a Global Biodata Core Resource Learn more...