CATH Domain 4h1mA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	protein-tyrosine kinase 2-beta isoform X1

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q14289

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q14289

FAK2_HUMAN

Homo sapiens

Protein-tyrosine kinase 2-beta

PDB Structure

PDB	4H1M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bhattacharya, S.K., Aspnes, G.E., Bagley, S.W., Boehm, M., Brosius, A.D., Buckbinder, L., Chang, J.S., Dibrino, J., Eng, H., Frederick, K.S., Griffith, D.A., Griffor, M.C., Guimaraes, C.R., Guzman-Perez, A., Han, S., Kalgutkar, A.S., Klug-McLeod, J., Garcia-Irizarry, C., Li, J., Lippa, B., Price, D.A., Southers, J.A., Walker, D.P., Wei, L., Xiao, J., Zawistoski, M.P., Zhao, X. Bioorg.Med.Chem.Lett.

Network disruptions