CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.200 | Phosphorylase Kinase; domain 1 | |
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | Glycogen synthase kinase-3 beta |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
2.7.11.26 |
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
|
UniProtKB Entries (1)
P49841 |
GSK3B_HUMAN
Homo sapiens
Glycogen synthase kinase-3 beta
|
PDB Structure
PDB | 2O5K |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta
Bioorg.Med.Chem.Lett.
|