The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zinc finger, CCCH-type
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Zinc finger CCCH domain-containing protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
26 E9ACZ0 (/ISM) E9AES7 (/ISM) Q381U0 (/ISM) Q381U0 (/ISM) Q381U0 (/ISM) Q381U0 (/ISM) Q381U0 (/ISM) Q4Q5A6 (/ISM) Q4Q6T1 (/ISM) Q4QFG8 (/ISM)
(16 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
14 Q381U0 (/IDA) Q381U0 (/IDA) Q381U0 (/IDA) Q381U0 (/IDA) Q381U0 (/IDA) Q57VA5 (/IDA) Q57VA5 (/IDA) Q57W26 (/IDA) Q57W26 (/IDA) Q967Y4 (/IDA)
(4 more)
Nucleic acid binding GO:0003676
Interacting selectively and non-covalently with any nucleic acid.
11 Q381U0 (/ISM) Q381U0 (/ISM) Q381U0 (/ISM) Q381U0 (/ISM) Q381U0 (/ISM) Q586G8 (/ISM) Q967Y4 (/ISM) Q967Y4 (/ISM) Q967Y4 (/ISM) Q967Y4 (/ISM)
(1 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
5 Q9C7C3 (/ISS) Q9C7C3 (/ISS) Q9FG30 (/ISS) Q9LT81 (/ISS) Q9LT81 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 P47979 (/IDA) Q9C7C3 (/IDA) Q9C7C3 (/IDA) Q9FG30 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O02289 (/IPI) P47979 (/IPI)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P47979 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 E9AES9 (/ISO)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
1 P47979 (/IDA)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
1 P47979 (/IPI)
Exoribonuclease activator activity GO:0044692
Binds to and increases the activity of an exoribonuclease.
1 P47979 (/IDA)
CCR4-NOT complex binding GO:1905762
Interacting selectively and non-covalently with a CCR4-NOT complex.
1 P47979 (/IDA)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
10 Q381U0 (/IMP) Q381U0 (/IMP) Q381U0 (/IMP) Q381U0 (/IMP) Q381U0 (/IMP) Q967Y4 (/IMP) Q967Y4 (/IMP) Q967Y4 (/IMP) Q967Y4 (/IMP) Q967Y4 (/IMP)
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
10 Q381U0 (/TAS) Q381U0 (/TAS) Q381U0 (/TAS) Q381U0 (/TAS) Q381U0 (/TAS) Q967Y4 (/TAS) Q967Y4 (/TAS) Q967Y4 (/TAS) Q967Y4 (/TAS) Q967Y4 (/TAS)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
6 Q57VA5 (/IDA) Q57VA5 (/IDA) Q57VA6 (/IDA) Q57VA6 (/IDA) Q57W26 (/IDA) Q57W26 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 Q9C7C3 (/TAS) Q9C7C3 (/TAS) Q9FG30 (/TAS) Q9LT81 (/TAS) Q9LT81 (/TAS)
Positive regulation of leaf senescence GO:1900057
Any process that activates or increases the frequency, rate or extent of leaf senescence.
3 Q9C7C3 (/IMP) Q9C7C3 (/IMP) Q9FG30 (/IMP)
Regulation of photoperiodism, flowering GO:2000028
Any process that modulates the frequency, rate or extent of photoperiodism, flowering.
3 Q9C7C3 (/IGI) Q9C7C3 (/IGI) Q9FG30 (/IGI)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 Q57W26 (/IMP) Q57W26 (/IMP)
MRNA stabilization GO:0048255
Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
2 Q57W26 (/IDA) Q57W26 (/IDA)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
1 P47979 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 E9AES9 (/ISO)
Positive regulation of conjugation with cellular fusion GO:0031139
Any process that increases the rate or frequency of conjugation with cellular fusion.
1 P47979 (/IGI)
Positive regulation of conjugation with cellular fusion GO:0031139
Any process that increases the rate or frequency of conjugation with cellular fusion.
1 P47979 (/IMP)
MRNA stabilization GO:0048255
Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
1 E9AES9 (/ISO)
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
1 P47979 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
15 O02289 (/IDA) Q381U0 (/IDA) Q381U0 (/IDA) Q381U0 (/IDA) Q381U0 (/IDA) Q381U0 (/IDA) Q57W26 (/IDA) Q57W26 (/IDA) Q57WV5 (/IDA) Q57WV5 (/IDA)
(5 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q381U0 (/IC) Q381U0 (/IC) Q381U0 (/IC) Q381U0 (/IC) Q381U0 (/IC) Q967Y4 (/IC) Q967Y4 (/IC) Q967Y4 (/IC) Q967Y4 (/IC) Q967Y4 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P47979 (/IDA) Q9C7C3 (/IDA) Q9C7C3 (/IDA) Q9FG30 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q57VA5 (/IDA) Q57VA5 (/IDA) Q57VA6 (/IDA) Q57VA6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 E9ACZ0 (/ISO) E9AES9 (/ISO) Q4Q5A6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q4QFG8 (/ISO) Q4QFH0 (/ISO)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
2 Q57WV5 (/IDA) Q57WV5 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q4QJI4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P47979 (/HDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 O02289 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
1 E9ACZ0 (/ISO)
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