The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zinc finger, CCCH-type
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Zinc finger protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
8 P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
7 Q09436 (/IPI) Q584Y9 (/IPI) Q584Y9 (/IPI) Q584Y9 (/IPI) Q584Y9 (/IPI) Q584Y9 (/IPI) Q9XUB2 (/IPI)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
6 P47976 (/ISS) P47976 (/ISS) P47976 (/ISS) P47976 (/ISS) P47976 (/ISS) P47976 (/ISS)
Nucleic acid binding GO:0003676
Interacting selectively and non-covalently with any nucleic acid.
5 Q584Y9 (/ISM) Q584Y9 (/ISM) Q584Y9 (/ISM) Q584Y9 (/ISM) Q584Y9 (/ISM)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 Q584Y9 (/ISM) Q584Y9 (/ISM) Q584Y9 (/ISM) Q584Y9 (/ISM) Q584Y9 (/ISM)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 Q584Y9 (/TAS) Q584Y9 (/TAS) Q584Y9 (/TAS) Q584Y9 (/TAS) Q584Y9 (/TAS)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
3 G5EC86 (/IDA) Q09436 (/IDA) Q9XUB2 (/IDA)
Translation repressor activity, mRNA regulatory element binding GO:0000900
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
2 G5EC86 (/IGI) Q23359 (/IGI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 G5EC86 (/IPI) Q23359 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q09436 (/IPI) Q9XUB2 (/IPI)
Poly-pyrimidine tract binding GO:0008187
Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule.
1 Q9XUB2 (/IDA)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
1 G5EC86 (/IDA)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
9 P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) Q6FVK2 (/IMP)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
8 P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP) P47977 (/IMP)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
6 P47976 (/IGI) P47976 (/IGI) P47976 (/IGI) P47976 (/IGI) P47976 (/IGI) P47976 (/IGI)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
6 P47976 (/IGI) P47976 (/IGI) P47976 (/IGI) P47976 (/IGI) P47976 (/IGI) P47976 (/IGI)
Oocyte growth GO:0001555
The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
2 G5EC86 (/IGI) Q23359 (/IGI)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
2 G5EC86 (/IGI) Q23359 (/IGI)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 G5EC86 (/IMP) Q23359 (/IMP)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
2 Q09436 (/IGI) Q9XUB2 (/IGI)
Positive regulation of embryonic development GO:0040019
Any process that activates or increases the frequency, rate or extent of embryonic development.
2 G5EC86 (/IGI) Q23359 (/IGI)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
2 G5EC86 (/IGI) Q23359 (/IGI)
Oocyte morphogenesis GO:0048601
The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.
2 G5EC86 (/IGI) Q23359 (/IGI)
Meiotic nuclear envelope disassembly GO:0051078
The cell cycle process in which the controlled breakdown of the nuclear envelope during meiotic cell division occurs.
2 G5EC86 (/IGI) Q23359 (/IGI)
Establishment of chromosome localization GO:0051303
The directed movement of a chromosome to a specific location.
2 G5EC86 (/IGI) Q23359 (/IGI)
Negative regulation of ovulation GO:0060280
Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
2 G5EC86 (/IGI) Q23359 (/IGI)
Positive regulation of oocyte development GO:0060282
Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2 G5EC86 (/IGI) Q23359 (/IGI)
Protein localization to chromatin GO:0071168
Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
2 G5EC86 (/IGI) Q23359 (/IGI)
Positive regulation of oocyte maturation GO:1900195
Any process that activates or increases the frequency, rate or extent of oocyte maturation.
2 G5EC86 (/IGI) Q23359 (/IGI)
Negative regulation of meiotic cell cycle process involved in oocyte maturation GO:1904145
Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
2 G5EC86 (/IGI) Q23359 (/IGI)
Positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146
Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
2 G5EC86 (/IGI) Q23359 (/IGI)
Positive regulation of fertilization GO:1905516
Any process that activates or increases the frequency, rate or extent of fertilization.
2 G5EC86 (/IGI) Q23359 (/IGI)
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
1 G5EC86 (/IMP)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 Q9XUB2 (/IMP)
Positive regulation of embryonic development GO:0040019
Any process that activates or increases the frequency, rate or extent of embryonic development.
1 G5EC86 (/IMP)
Regulation of mesodermal cell fate specification GO:0042661
Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.
1 G5EC86 (/IGI)
Negative regulation of mesodermal cell fate specification GO:0042662
Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.
1 G5EC86 (/IMP)
Negative regulation of endodermal cell fate specification GO:0042664
Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.
1 G5EC86 (/IMP)
Pharyngeal muscle development GO:0043282
The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx.
1 G5EC86 (/IMP)
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
1 G5EC86 (/IMP)
Negative regulation of smooth muscle cell differentiation GO:0051151
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.
1 G5EC86 (/IMP)
Regulation of mRNA catabolic process GO:0061013
Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 Q5A5R5 (/IMP)
Endodermal digestive tract morphogenesis GO:0061031
The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.
1 G5EC86 (/IGI)
Endodermal digestive tract morphogenesis GO:0061031
The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.
1 G5EC86 (/IMP)
Regulation of endodermal cell differentiation GO:1903224
Any process that modulates the frequency, rate or extent of endodermal cell differentiation.
1 G5EC86 (/IGI)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
12 G5EC86 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) Q09436 (/IDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA) P47977 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA) P47977 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P47976 (/IC) P47976 (/IC) P47976 (/IC) P47976 (/IC) P47976 (/IC) P47976 (/IC)
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
4 G5EC86 (/IDA) Q09436 (/IDA) Q23359 (/IDA) Q9XUB2 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
3 G5EC86 (/IDA) Q23359 (/IDA) Q9XUB2 (/IDA)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
1 G5EC86 (/IDA)
Messenger ribonucleoprotein complex GO:1990124
A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.
1 G5EC86 (/IDA)