The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hect, E3 ligase catalytic domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: E3 ubiquitin-protein ligase HUWE1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
8 Q7TMY8 (/ISS) Q9VXR3 (/ISS) X2JC16 (/ISS) X2JDY2 (/ISS) X2JF73 (/ISS) X2JF83 (/ISS) X2JFK0 (/ISS) X2JKH9 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 Q7TMY8 (/ISS) Q7Z6Z7 (/ISS) Q7Z6Z7 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q7Z6Z7 (/IPI) Q7Z6Z7 (/IPI) Q9GUP2 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q7Z6Z7 (/HDA) Q7Z6Z7 (/HDA)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2 Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q7TMY8 (/ISO)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
7 Q9VXR3 (/ISS) X2JC16 (/ISS) X2JDY2 (/ISS) X2JF73 (/ISS) X2JF83 (/ISS) X2JFK0 (/ISS) X2JKH9 (/ISS)
DsRNA transport GO:0033227
The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
7 Q9VXR3 (/IMP) X2JC16 (/IMP) X2JDY2 (/IMP) X2JF73 (/IMP) X2JF83 (/IMP) X2JFK0 (/IMP) X2JKH9 (/IMP)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
3 Q7TMY8 (/IDA) Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
3 Q7TMY8 (/IMP) Q7Z6Z7 (/IMP) Q7Z6Z7 (/IMP)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
2 Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
2 Q7Z6Z7 (/TAS) Q7Z6Z7 (/TAS)
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
2 Q7Z6Z7 (/IMP) Q7Z6Z7 (/IMP)
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
2 Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
2 Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 Q7Z6Z7 (/TAS) Q7Z6Z7 (/TAS)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
2 Q7Z6Z7 (/HMP) Q7Z6Z7 (/HMP)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q7TMY8 (/ISO)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q7TMY8 (/ISS)
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
1 Q7TMY8 (/ISO)
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
1 Q7TMY8 (/ISS)
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
1 Q7TMY8 (/ISO)
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
1 Q7TMY8 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9GUP2 (/IMP)
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
1 Q7TMY8 (/ISO)
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
1 Q7TMY8 (/ISS)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
1 U4PBY0 (/IMP)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q7TMY8 (/ISO)
Hemidesmosome assembly GO:0031581
Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.
1 Q9GUP2 (/IGI)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 Q7TMY8 (/ISO)
Signal transduction in response to DNA damage GO:0042770
A cascade of processes induced by the detection of DNA damage within a cell.
1 Q9GUP2 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q9GUP2 (/IMP)
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
1 Q9GUP2 (/IGI)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 Q7TMY8 (/ISS) Q7Z6Z7 (/ISS) Q7Z6Z7 (/ISS) Q9VXR3 (/ISS) X2JC16 (/ISS) X2JDY2 (/ISS) X2JF73 (/ISS) X2JF83 (/ISS) X2JFK0 (/ISS) X2JKH9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q7TMY8 (/ISS) Q9VXR3 (/ISS) X2JC16 (/ISS) X2JDY2 (/ISS) X2JF73 (/ISS) X2JF83 (/ISS) X2JFK0 (/ISS) X2JKH9 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 A0A024R9U8 (/IDA) A0A024R9W5 (/IDA) A0A024R9W5 (/IDA) Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A0A024R9U8 (/IDA) A0A024R9W5 (/IDA) A0A024R9W5 (/IDA) Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q7Z6Z7 (/TAS) Q7Z6Z7 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q7Z6Z7 (/IDA) Q7Z6Z7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q7Z6Z7 (/TAS) Q7Z6Z7 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q7Z6Z7 (/HDA) Q7Z6Z7 (/HDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
2 Q7Z6Z7 (/TAS) Q7Z6Z7 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q7Z6Z7 (/HDA) Q7Z6Z7 (/HDA)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
2 Q7Z6Z7 (/TAS) Q7Z6Z7 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q7TMY8 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q7TMY8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q7TMY8 (/ISO)
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