The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 231: Estradiol 17-beta-dehydrogenase 8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
5 P50171 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA)
3-hydroxyacyl-CoA dehydrogenase activity GO:0003857
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).
4 Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA)
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
4 P50171 (/ISS) Q5TJF5 (/ISS) Q6MGB5 (/ISS) Q9XT00 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q92506 (/IPI) Q92506 (/IPI) Q92506 (/IPI) Q92506 (/IPI)
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity GO:0047025
Catalysis of the reaction: NAD+ + OH-acyl-
4 Q92506 (/IMP) Q92506 (/IMP) Q92506 (/IMP) Q92506 (/IMP)
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity GO:0047025
Catalysis of the reaction: NAD+ + OH-acyl-
4 P50171 (/ISS) Q5TJF5 (/ISS) Q6MGB5 (/ISS) Q9XT00 (/ISS)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
4 Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
4 P50171 (/ISS) Q5TJF5 (/ISS) Q6MGB5 (/ISS) Q9XT00 (/ISS)
3-hydroxyacyl-CoA dehydrogenase activity GO:0003857
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).
1 P50171 (/ISO)
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
1 P50171 (/ISO)
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity GO:0047025
Catalysis of the reaction: NAD+ + OH-acyl-
1 P50171 (/ISO)
Testosterone dehydrogenase (NAD+) activity GO:0047035
Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.
1 P50171 (/IDA)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
1 P50171 (/ISO)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
4 Q92506 (/IMP) Q92506 (/IMP) Q92506 (/IMP) Q92506 (/IMP)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
4 P50171 (/ISS) Q5TJF5 (/ISS) Q6MGB5 (/ISS) Q9XT00 (/ISS)
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
4 Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA)
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
4 P50171 (/ISS) Q5TJF5 (/ISS) Q6MGB5 (/ISS) Q9XT00 (/ISS)
Fatty-acyl-CoA biosynthetic process GO:0046949
The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.
4 Q92506 (/TAS) Q92506 (/TAS) Q92506 (/TAS) Q92506 (/TAS)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
4 Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
4 P50171 (/ISS) Q5TJF5 (/ISS) Q6MGB5 (/ISS) Q9XT00 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
4 Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
3 Q5TJF5 (/ISS) Q6MGB5 (/ISS) Q9XT00 (/ISS)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 P50171 (/ISO)
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
1 P50171 (/ISO)
Androgen metabolic process GO:0008209
The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
1 P50171 (/IDA)
Estrogen metabolic process GO:0008210
The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
1 P50171 (/IDA)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
1 P50171 (/ISO)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P50171 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA) Q92506 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 Q92506 (/TAS) Q92506 (/TAS) Q92506 (/TAS) Q92506 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q32S21 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P50171 (/HDA)
Mitochondrial envelope GO:0005740
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
1 P50171 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P50171 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P50171 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P50171 (/IDA)