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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 231: Estradiol 17-beta-dehydrogenase 8

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
17-beta-estradiol 17-dehydrogenase. [EC: 1.1.1.62]
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
  • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
 20 A0A1U9X7U3 A0A1U9X7U3 A0A1U9X7U3 A0A1U9X7U3 A0A2R9ALS4 A0A2R9ALS4 A0A2R9ALS4 A0A2R9ALS4 H2QSS7 H2QSS7
(10 more...)
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)). [EC: 1.1.1.239]
Testosterone + NAD(+) = androstenedione + NADH.
  • Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids.
  • Different from EC 1.1.1.50 or EC 1.1.1.213.
  • Formerly EC 1.1.1.63.
 20 A0A1U9X7U3 A0A1U9X7U3 A0A1U9X7U3 A0A1U9X7U3 A0A2R9ALS4 A0A2R9ALS4 A0A2R9ALS4 A0A2R9ALS4 H2QSS7 H2QSS7
(10 more...)