The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"von Willebrand factor, type A domain
".
FunFam 6: voltage-dependent calcium channel subunit alpha-2/...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | A0A2R8QDT8 (/IPI) E7F4T2 (/IPI) O08532 (/IPI) P13806 (/IPI) P54290 (/IPI) Q5TZ68 (/IPI) |
|
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
4 | P54289 (/IDA) Q6PHS9 (/IDA) Q6PHS9 (/IDA) Q8CFG6 (/IDA) |
|
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
3 | O08532 (/ISO) Q6PHS9 (/ISO) Q6PHS9 (/ISO) |
|
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | P54289 (/IGI) |
|
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | P54290 (/IMP) |
|
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
|
1 | P13806 (/IDA) |
|
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
|
1 | Q8CFG6 (/TAS) |
There are 50 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | O08532 (/ISO) Q6PHS9 (/ISO) Q6PHS9 (/ISO) |
|
Cardiac conduction GO:0061337
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
|
3 | P54289 (/TAS) Q9NY47 (/TAS) Q9UIU0 (/TAS) |
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q6PHS9 (/IC) Q6PHS9 (/IC) |
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P54289 (/IDA) Q8CFG6 (/IDA) |
|
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
|
2 | Q6PHS9 (/IMP) Q6PHS9 (/IMP) |
|
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
2 | Q6PHS9 (/ISO) Q6PHS9 (/ISO) |
|
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
|
2 | Q6PHS9 (/IMP) Q6PHS9 (/IMP) |
|
Positive regulation of organ growth GO:0046622
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
|
2 | Q6PHS9 (/IMP) Q6PHS9 (/IMP) |
|
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
2 | Q6PHS9 (/IMP) Q6PHS9 (/IMP) |
|
Rhythmic synaptic transmission GO:0060024
Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit.
|
2 | Q6PHS9 (/IMP) Q6PHS9 (/IMP) |
|
Calcium ion transport into cytosol GO:0060402
The directed movement of calcium ions (Ca2+) into the cytosol.
|
2 | O08532 (/ISS) P54289 (/ISS) |
|
Calcium ion transmembrane transport via high voltage-gated calcium channel GO:0061577
A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel.
|
2 | O08532 (/ISS) P54289 (/ISS) |
|
Regulation of membrane repolarization during action potential GO:0098903
Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential.
|
2 | O08532 (/ISS) P54289 (/ISS) |
|
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
|
2 | O08532 (/ISS) P54289 (/ISS) |
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P54290 (/TAS) |
|
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
1 | Q8CFG6 (/IMP) |
|
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
1 | Q9NY47 (/TAS) |
|
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P54289 (/IDA) |
|
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | O08532 (/IMP) |
|
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | O08532 (/ISO) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
1 | P54289 (/IMP) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
1 | O08532 (/ISO) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
1 | O08532 (/ISS) |
|
Calcium ion transport into cytosol GO:0060402
The directed movement of calcium ions (Ca2+) into the cytosol.
|
1 | P54290 (/IDA) |
|
Calcium ion transport into cytosol GO:0060402
The directed movement of calcium ions (Ca2+) into the cytosol.
|
1 | O08532 (/ISO) |
|
Calcium ion transmembrane transport via high voltage-gated calcium channel GO:0061577
A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel.
|
1 | P54290 (/IDA) |
|
Calcium ion transmembrane transport via high voltage-gated calcium channel GO:0061577
A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel.
|
1 | O08532 (/ISO) |
|
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
1 | P54290 (/IDA) |
|
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
1 | O08532 (/ISO) |
|
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
1 | O08532 (/ISS) |
|
Cardiac muscle cell action potential involved in contraction GO:0086002
An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
|
1 | P54289 (/IMP) |
|
Cardiac muscle cell action potential involved in contraction GO:0086002
An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
|
1 | O08532 (/ISO) |
|
Cardiac muscle cell action potential involved in contraction GO:0086002
An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
|
1 | O08532 (/ISS) |
|
Membrane depolarization during bundle of His cell action potential GO:0086048
The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
|
1 | P54289 (/IMP) |
|
Membrane depolarization during bundle of His cell action potential GO:0086048
The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
|
1 | O08532 (/ISO) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
1 | P54289 (/IMP) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
1 | O08532 (/ISO) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
1 | O08532 (/ISS) |
|
Calcium ion import across plasma membrane GO:0098703
The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
1 | P13806 (/IDA) |
|
Calcium ion import across plasma membrane GO:0098703
The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
1 | P54289 (/ISS) |
|
Regulation of membrane repolarization during action potential GO:0098903
Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential.
|
1 | P54290 (/IDA) |
|
Regulation of membrane repolarization during action potential GO:0098903
Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential.
|
1 | O08532 (/ISO) |
|
Positive regulation of voltage-gated calcium channel activity GO:1901387
Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
|
1 | P54290 (/IDA) |
|
Positive regulation of voltage-gated calcium channel activity GO:1901387
Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
|
1 | O08532 (/ISO) |
|
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
|
1 | P54290 (/IDA) |
|
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
|
1 | O08532 (/ISO) |
|
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
|
1 | P54289 (/IGI) |
|
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
|
1 | O08532 (/ISO) |
|
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
|
1 | P54289 (/IGI) |
|
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
|
1 | O08532 (/ISO) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
|
4 | P54289 (/IDA) P54290 (/IDA) Q6PHS9 (/IDA) Q6PHS9 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P54289 (/TAS) Q9NY47 (/TAS) Q9UIU0 (/TAS) |
|
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
|
3 | P13806 (/IDA) P54289 (/IDA) P54290 (/IDA) |
|
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
|
2 | O08532 (/IDA) P13806 (/IDA) |
|
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
|
1 | O08532 (/ISO) |
|
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
|
1 | Q8CFG6 (/TAS) |
|
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
|
1 | O08532 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P54289 (/HDA) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P54290 (/IDA) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | O08532 (/ISO) |
|
Anchored component of postsynaptic membrane GO:0099025
The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
1 | P54290 (/IDA) |
|
Anchored component of postsynaptic membrane GO:0099025
The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
1 | O08532 (/ISO) |
|
Anchored component of presynaptic active zone membrane GO:0099029
The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
1 | P54290 (/IDA) |
|
Anchored component of presynaptic active zone membrane GO:0099029
The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
1 | O08532 (/ISO) |
|
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
|
1 | O08532 (/ISO) |
|
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
|
1 | O08532 (/ISS) |
