The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
von Willebrand factor, type A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: 26S proteasome non-ATPase regulatory subunit 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
25 O82143 (/IPI) O82143 (/IPI) O82143 (/IPI) O94444 (/IPI) P38886 (/IPI) P38886 (/IPI) P38886 (/IPI) P38886 (/IPI) P38886 (/IPI) P38886 (/IPI)
(15 more)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
10 P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P55034 (/IDA) P55034 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
9 P55036 (/HDA) P55036 (/HDA) P55036 (/HDA) P55036 (/HDA) P55036 (/HDA) P55036 (/HDA) P55036 (/HDA) P55036 (/HDA) P55036 (/HDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
9 P55036 (/IPI) P55036 (/IPI) P55036 (/IPI) P55036 (/IPI) P55036 (/IPI) P55036 (/IPI) P55036 (/IPI) P55036 (/IPI) P55036 (/IPI)
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
8 P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
3 P55035 (/ISS) P55035 (/ISS) Q553E0 (/ISS)
Peptide receptor activity GO:0001653
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
2 P55034 (/IDA) P55034 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 O88321 (/IPI) Q9ESH1 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P55035 (/IDA) P55035 (/IDA)
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
2 P55035 (/IPI) P55035 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 O35226 (/ISO)
K48-linked polyubiquitin modification-dependent protein binding GO:0036435
Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.
1 O94444 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O35226 (/ISO)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 O94444 (/ISM)

There are 55 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
12 O61742 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) Q57YH3 (/IMP)
(2 more)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Regulation of cellular amino acid metabolic process GO:0006521
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Anaphase-promoting complex-dependent catabolic process GO:0031145
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
NIK/NF-kappaB signaling GO:0038061
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Regulation of mitotic cell cycle phase transition GO:1901990
Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Regulation of hematopoietic stem cell differentiation GO:1902036
Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.
9 P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
4 P55034 (/IMP) P55034 (/IMP) P55035 (/IMP) P55035 (/IMP)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
3 O94444 (/IC) P55035 (/IC) P55035 (/IC)
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
2 P55035 (/IMP) P55035 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 P55034 (/IMP) P55034 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 P55035 (/TAS) P55035 (/TAS)
Toll signaling pathway GO:0008063
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P55035 (/TAS) P55035 (/TAS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 P55034 (/IMP) P55034 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
2 P55034 (/IMP) P55034 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 P55034 (/IMP) P55034 (/IMP)
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
2 P55034 (/IMP) P55034 (/IMP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
2 P55034 (/IEP) P55034 (/IEP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
2 P55034 (/IMP) P55034 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 P55034 (/IMP) P55034 (/IMP)
Response to sucrose GO:0009744
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
2 P55034 (/IMP) P55034 (/IMP)
Regulation of seed germination GO:0010029
Any process that modulates the frequency, rate or extent of seed germination.
2 P55034 (/IMP) P55034 (/IMP)
Leaf senescence GO:0010150
The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism.
2 P55034 (/IMP) P55034 (/IMP)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
2 P55034 (/TAS) P55034 (/TAS)
Fluid transport GO:0042044
The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O88321 (/NAS) Q9ESH1 (/NAS)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
2 P55035 (/IGI) P55035 (/IGI)
Proteasome assembly GO:0043248
The aggregation, arrangement and bonding together of a mature, active proteasome complex.
2 P55034 (/IMP) P55034 (/IMP)
Leaf development GO:0048366
The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
2 P55034 (/IMP) P55034 (/IMP)
Stamen formation GO:0048455
The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts.
2 P55034 (/IMP) P55034 (/IMP)
Post-embryonic root development GO:0048528
The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure.
2 P55034 (/IMP) P55034 (/IMP)
Root hair elongation GO:0048767
The process in which the root hair grows longer.
2 P55034 (/IMP) P55034 (/IMP)
Response to misfolded protein GO:0051788
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
2 P55034 (/IMP) P55034 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 O61742 (/IGI)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q553E0 (/ISS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 O61742 (/IGI)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 O61742 (/IMP)
Positive regulation of mitotic metaphase/anaphase transition GO:0045842
Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
1 O94444 (/IC)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
26 P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) Q57YH3 (/IDA)
(16 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
25 P55034 (/IDA) P55034 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA)
(15 more)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
13 P55034 (/IDA) P55034 (/IDA) P55035 (/IDA) P55035 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA) P55036 (/IDA)
(3 more)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
11 P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) P38886 (/IMP) Q57YH3 (/IMP) Q57YH3 (/IMP)
(1 more)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
11 P55034 (/TAS) P55034 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
(1 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
11 P55035 (/TAS) P55035 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P55035 (/TAS) P55035 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS) P55036 (/TAS)
(1 more)
Proteasome regulatory particle, base subcomplex GO:0008540
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
11 O82143 (/IDA) O82143 (/IDA) O82143 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA) P38886 (/IDA)
(1 more)
Proteasome accessory complex GO:0022624
A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
10 P55036 (/ISS) P55036 (/ISS) P55036 (/ISS) P55036 (/ISS) P55036 (/ISS) P55036 (/ISS) P55036 (/ISS) P55036 (/ISS) P55036 (/ISS) Q58DA0 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 O61742 (/IDA) O88321 (/IDA) Q57YH3 (/IDA) Q57YH3 (/IDA) Q57YH3 (/IDA) Q9ESH1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O94444 (/HDA) P55035 (/HDA) P55035 (/HDA)
Proteasome regulatory particle GO:0005838
A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
3 Q57YH3 (/IMP) Q57YH3 (/IMP) Q57YH3 (/IMP)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
3 Q57YH3 (/IDA) Q57YH3 (/IDA) Q57YH3 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P55034 (/TAS) P55034 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P55035 (/HDA) P55035 (/HDA)
Proteasome regulatory particle GO:0005838
A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
2 P55035 (/IDA) P55035 (/IDA)
Proteasome regulatory particle GO:0005838
A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
2 P55035 (/ISS) P55035 (/ISS)
Proteasome regulatory particle, base subcomplex GO:0008540
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
2 P55035 (/ISS) P55035 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P55034 (/IDA) P55034 (/IDA)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
1 O35226 (/ISO)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
1 Q553E0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O61742 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O35226 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O35226 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94444 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O35226 (/ISO)
Proteasome regulatory particle, base subcomplex GO:0008540
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
1 O94444 (/IMP)
Proteasome regulatory particle, lid subcomplex GO:0008541
The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.
1 O94444 (/IDA)
Proteasome accessory complex GO:0022624
A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
1 O35226 (/IDA)