The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
von Willebrand factor, type A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: collagen alpha-6(VI) chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
17 A0A0B5JF83 (/ISS) A0A0B5JF83 (/ISS) B3DKJ1 (/ISS) B3DKJ1 (/ISS) Q5CZQ6 (/ISS) Q5NJJ0 (/ISS) Q5NJJ1 (/ISS) Q5NJJ1 (/ISS) Q5NJJ2 (/ISS) Q5NJJ2 (/ISS)
(7 more)
Extracellular matrix structural constituent conferring tensile strength GO:0030020
A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.
17 A2AX52 (/RCA) A2AX52 (/RCA) A2AX52 (/RCA) A6H584 (/RCA) A6H584 (/RCA) A6NMZ7 (/RCA) A6NMZ7 (/RCA) A6NMZ7 (/RCA) A8TX70 (/RCA) A8TX70 (/RCA)
(7 more)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
10 F1S0M0 (/RCA) F1S0M0 (/RCA) O00339 (/RCA) O00339 (/RCA) O00339 (/RCA) O00339 (/RCA) O08746 (/RCA) O08746 (/RCA) O89029 (/RCA) O89029 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 A8TX70 (/IPI) A8TX70 (/IPI) O00339 (/IPI) O00339 (/IPI) O00339 (/IPI) O00339 (/IPI) O95460 (/IPI) O95460 (/IPI) P21941 (/IPI) P51942 (/IPI)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
4 O00339 (/ISS) O00339 (/ISS) O00339 (/ISS) O00339 (/ISS)
Extracellular matrix structural constituent conferring tensile strength GO:0030020
A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.
4 A8TX70 (/ISS) A8TX70 (/ISS) P12111 (/ISS) P12111 (/ISS)
Extracellular matrix structural constituent conferring tensile strength GO:0030020
A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.
2 A8TX70 (/HDA) A8TX70 (/HDA)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 P21941 (/TAS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
8 F1Q924 (/IMP) F1Q924 (/IMP) F1Q924 (/IMP) F1Q924 (/IMP) X1WEZ4 (/IMP) X1WEZ4 (/IMP) X1WEZ4 (/IMP) X1WEZ4 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
8 F1Q924 (/IMP) F1Q924 (/IMP) F1Q924 (/IMP) F1Q924 (/IMP) X1WEZ4 (/IMP) X1WEZ4 (/IMP) X1WEZ4 (/IMP) X1WEZ4 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
5 O95460 (/TAS) O95460 (/TAS) P12111 (/TAS) P12111 (/TAS) P21941 (/TAS)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
3 A2AX52 (/IDA) A2AX52 (/IDA) A2AX52 (/IDA)
Protein heterotrimerization GO:0070208
The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical.
3 A2AX52 (/IDA) A2AX52 (/IDA) A2AX52 (/IDA)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 O08746 (/IDA) O08746 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 O08746 (/IGI) O08746 (/IGI)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
2 P12111 (/TAS) P12111 (/TAS)
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
2 O08746 (/IDA) O08746 (/IDA)
Dendrite regeneration GO:0031104
The regrowth of dendrites in response to their loss or damage.
2 O08746 (/IMP) O08746 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 O08746 (/IDA) O08746 (/IDA)
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
2 O89029 (/IDA) O89029 (/IDA)
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
2 O08746 (/IMP) O08746 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
2 A5WWJ4 (/IMP) Q7ZVP3 (/IMP)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
1 P51942 (/IMP)
Growth plate cartilage chondrocyte morphogenesis GO:0003429
The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.
1 P51942 (/IMP)
Regulation of bone mineralization GO:0030500
Any process that modulates the frequency, rate or extent of bone mineralization.
1 P51942 (/IMP)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
1 P21941 (/TAS)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
25 A2AX52 (/HDA) A2AX52 (/HDA) A2AX52 (/HDA) A6H584 (/HDA) A6H584 (/HDA) A6NMZ7 (/HDA) A6NMZ7 (/HDA) A6NMZ7 (/HDA) A8TX70 (/HDA) A8TX70 (/HDA)
(15 more)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
16 A2AX52 (/IDA) A2AX52 (/IDA) A2AX52 (/IDA) A6H584 (/IDA) A6H584 (/IDA) A6NMZ7 (/IDA) A6NMZ7 (/IDA) A6NMZ7 (/IDA) D3YWD1 (/IDA) E9PWQ3 (/IDA)
(6 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
11 A6NMZ7 (/TAS) A6NMZ7 (/TAS) A6NMZ7 (/TAS) A8TX70 (/TAS) A8TX70 (/TAS) O95460 (/TAS) O95460 (/TAS) P12111 (/TAS) P12111 (/TAS) P21941 (/TAS)
(1 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
8 A2AX52 (/IDA) A2AX52 (/IDA) A2AX52 (/IDA) A8TX70 (/IDA) A8TX70 (/IDA) Q8C6K9 (/IDA) Q8C6K9 (/IDA) Q8C6K9 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
6 D3YWD1 (/ISO) E9PWQ3 (/ISO) Q8C6K9 (/ISO) Q8C6K9 (/ISO) Q8C6K9 (/ISO) Q9Z0I9 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 O08746 (/HDA) O08746 (/HDA) P12111 (/HDA) P12111 (/HDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
4 O00339 (/NAS) O00339 (/NAS) O00339 (/NAS) O00339 (/NAS)
Collagen trimer GO:0005581
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
3 D3YWD1 (/IDA) E9PWQ3 (/IDA) Q9Z0I9 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 D3YWD1 (/IDA) E9PWQ3 (/IDA) Q9Z0I9 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
3 P12111 (/TAS) P12111 (/TAS) Q8NFW1 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 A2AX52 (/IDA) A2AX52 (/IDA) A2AX52 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
3 D3YWD1 (/IDA) E9PWQ3 (/IDA) Q9Z0I9 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P12111 (/HDA) P12111 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 A6H584 (/ISO) A6H584 (/ISO)
Collagen type VI trimer GO:0005589
A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils.
2 P12111 (/TAS) P12111 (/TAS)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
2 O08746 (/IDA) O08746 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P12111 (/HDA) P12111 (/HDA)
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
2 P12111 (/HDA) P12111 (/HDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P21941 (/TAS)
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