The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"HAD superfamily/HAD-like
".
FunFam 1: Phospholipid-transporting ATPase IC
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
|
6 | Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) |
ATPase-coupled intramembrane lipid transporter activity GO:0140326
Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases.
|
6 | A0A0B4K638 (/ISS) A0A0B4K756 (/ISS) A0A0B4LH21 (/ISS) A0A0B4LH79 (/ISS) Q9VGD4 (/ISS) Q9VXG6 (/ISS) |
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
4 | Q5IR98 (/IDA) Q5IRA0 (/IDA) Q5IRA1 (/IDA) Q5IRA2 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | O60312 (/IPI) O94823 (/IPI) Q12674 (/IPI) Q9P241 (/IPI) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
4 | Q8I5I3 (/ISS) Q8I5I3 (/ISS) Q8I5I3 (/ISS) Q8I5I3 (/ISS) |
Ion transmembrane transporter activity, phosphorylative mechanism GO:0015662
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.
|
3 | O77368 (/ISS) O77368 (/ISS) O77368 (/ISS) |
ATPase-coupled intramembrane lipid transporter activity GO:0140326
Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases.
|
3 | O60312 (/NAS) Q8K2X1 (/NAS) Q9P241 (/NAS) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
2 | Q8K2X1 (/NAS) Q9P241 (/NAS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | Q8K2X1 (/NAS) Q9P241 (/NAS) |
Cation transmembrane transporter activity GO:0008324
Enables the transfer of cation from one side of a membrane to the other.
|
1 | Q60CL1 (/ISS) |
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
|
1 | Q60CL1 (/ISS) |
ATPase-coupled intramembrane lipid transporter activity GO:0140326
Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases.
|
1 | Q12674 (/IGI) |
ATPase-coupled intramembrane lipid transporter activity GO:0140326
Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases.
|
1 | Q12674 (/IMP) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
6 | Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) Q76NN8 (/TAS) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
6 | Q76NN8 (/IDA) Q76NN8 (/IDA) Q76NN8 (/IDA) Q76NN8 (/IDA) Q76NN8 (/IDA) Q76NN8 (/IDA) |
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
6 | A0A0B4K638 (/ISS) A0A0B4K756 (/ISS) A0A0B4LH21 (/ISS) A0A0B4LH79 (/ISS) Q9VGD4 (/ISS) Q9VXG6 (/ISS) |
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
5 | A0A0B4K638 (/IMP) A0A0B4K756 (/IMP) A0A0B4LH21 (/IMP) A0A0B4LH79 (/IMP) Q9VGD4 (/IMP) |
Detection of chemical stimulus involved in sensory perception of smell GO:0050911
The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal.
|
5 | A0A0B4K638 (/IMP) A0A0B4K756 (/IMP) A0A0B4LH21 (/IMP) A0A0B4LH79 (/IMP) Q9VGD4 (/IMP) |
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | O77368 (/ISS) O77368 (/ISS) O77368 (/ISS) Q60CL1 (/ISS) |
Aminophospholipid transport GO:0015917
The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.
|
4 | Q8I5I3 (/ISS) Q8I5I3 (/ISS) Q8I5I3 (/ISS) Q8I5I3 (/ISS) |
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
4 | Q5IR98 (/IDA) Q5IRA0 (/IDA) Q5IRA1 (/IDA) Q5IRA2 (/IDA) |
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
3 | O60312 (/NAS) O94823 (/NAS) Q9P241 (/NAS) |
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
|
2 | G5EBE7 (/IMP) G5EC38 (/IMP) |
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q8K2X1 (/NAS) Q9P241 (/NAS) |
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
2 | O60312 (/TAS) Q9P241 (/TAS) |
Dauer larval development GO:0040024
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
|
2 | G5EBE7 (/IGI) G5EC38 (/IGI) |
Response to pheromone triggering conjugation with cellular fusion GO:0000749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
|
1 | Q12674 (/IGI) |
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
|
1 | Q12674 (/IGI) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | O60312 (/NAS) |
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | O18182 (/IGI) |
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
1 | Q12674 (/IMP) |
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
8 | B1AWN4 (/ISS) D2GUJ7 (/ISS) D4A4W5 (/ISS) E1BNB9 (/ISS) E2RRF3 (/ISS) F6XM62 (/ISS) F7E767 (/ISS) F7EBE8 (/ISS) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
6 | A0A0B4K638 (/ISM) A0A0B4K756 (/ISM) A0A0B4LH21 (/ISM) A0A0B4LH79 (/ISM) Q9VGD4 (/ISM) Q9VXG6 (/ISM) |
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
5 | A0A0B4K638 (/IDA) A0A0B4K756 (/IDA) A0A0B4LH21 (/IDA) A0A0B4LH79 (/IDA) Q9VGD4 (/IDA) |
Sensory dendrite GO:0071683
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
|
5 | A0A0B4K638 (/IDA) A0A0B4K756 (/IDA) A0A0B4LH21 (/IDA) A0A0B4LH79 (/IDA) Q9VGD4 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
4 | B1AWN4 (/ISO) O54827 (/ISO) O54827 (/ISO) Q8VH36 (/ISO) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | Q8I5I3 (/ISS) Q8I5I3 (/ISS) Q8I5I3 (/ISS) Q8I5I3 (/ISS) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
4 | Q5IR98 (/IDA) Q5IRA0 (/IDA) Q5IRA1 (/IDA) Q5IRA2 (/IDA) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
3 | Q5IRA0 (/IDA) Q5IRA1 (/IDA) Q5IRA2 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | O60312 (/IDA) O94823 (/IDA) Q9P241 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | O77368 (/ISS) O77368 (/ISS) O77368 (/ISS) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | O60312 (/NAS) Q8K2X1 (/NAS) Q9P241 (/NAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q5IRA1 (/IDA) Q5IRA2 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
2 | A2ANX2 (/ISO) F2Z411 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9P241 (/IDA) Q9T0E0 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | A2ANX2 (/ISO) F2Z411 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | O60312 (/TAS) Q9P241 (/TAS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9P241 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q12674 (/HDA) |
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
|
1 | Q12674 (/IDA) |
Trans-Golgi network transport vesicle GO:0030140
A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.
|
1 | Q12674 (/IDA) |
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
|
1 | Q8VH36 (/ISO) |
Mating projection tip membrane GO:0070867
The portion of the plasma membrane surrounding a mating projection tip.
|
1 | Q12674 (/IDA) |