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We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1919 - - 96.6
2
1690 - - 81.9
3
1677
3D
1rkqB01 - 98.1
5
1548
3D
5xabA03 - 81.8
4
1533
3D
4retC03 - 87.5
6
1301 - - 97.4
7
1269 - - 61.3
8
1186 - - 88.5
9
813 - - 88.6
10
788 - - 77.3
11
754 - - 77.3
13
683
3D
6du3B00 - 75.5
12
657 - - 78.4
14
645 - - 86.6
15
625 - - 89.2
16
576
3D
2c4nA02 - 78.4
29
504
3D
4hgrH00 - 97.4
17
489 - - 83.4
18
486 - - 81.8
19
445
3D
4qqfF00 - 93.0
20
443
3D
2yj6B01 - 87.4
22
434
3D
2yy6B01 - 90.9
21
423 - - 89.4
23
408 - - 89.7
24
402 - - 92.9
25
382
3D
3fvvB01 - 91.8
26
377 - - 80.6
27
364 - - 68.8
28
346 - - 94.7
30
323
3D
2c4nA01 - 49.0
31
312 - - 89.9
32
304
3D
2vkqA01 - 81.2
33
277
3D
2qltA01 - 85.5
34
275 - - 75.5
35
273 - - 76.6
36
260
3D
4uavA01 - 95.8
37
259
3D
3l8gA00 - 90.6
38
241 - - 89.9
41
237
3D
5t41A03 - 78.0
49
235
3D
3cz4A00 - 24.0
39
232 - - 94.3
40
229 - - 73.5
42
227 - - 23.9
46
227
3D
6cfvA01 - 78.7
43
224 - - 70.3
44
223 - - 71.9
45
220 - - 88.3
47
206 - - 83.2
53
206
3D
3pdwA02 - 95.2
48
200
3D
3n28A01 - 72.3
50
194
3D
3shqA02 - 76.9
51
190
3D
2x4dB02 - 94.5
52
187 - - 89.1
54
181 - - 94.4
57
177
3D
3a1eB01 - 91.4
55
177
3D
3l5kA01 - 84.9
59
177
3D
3pdwA01 - 76.8
56
172 - - 88.4
61
172
3D
2fpxB00 - 84.6
58
169
3D
2b0cA01 - 29.8
60
168
3D
3hltC02 - 84.6
107
166
3D
6aumA01 - 62.2
72
165
3D
2iohD01 - 87.1
66
159
3D
3f9rB01 - 88.4
62
158 - - 63.1
65
156
3D
3rf6B01 - 87.4
63
153 - - 71.2
64
152 - - 24.4
67
148 - - 81.1
68
147 - - 91.1
69
146 - - 94.4
70
145 - - 0.0
71
143 - - 77.4
73
140 - - 85.3
77
139
3D
1nnlB01 - 93.4
74
136 - - 77.7
75
136 - - 81.7
79
135
3D
2g80D01 - 83.5
76
133 - - 70.7
78
132 - - 93.0
80
127 - - 83.5
82
119
3D
3ewiB00 - 95.8
81
118 - - 84.0
83
117 - - 90.3
84
116 - - 88.2
85
113 - - 47.8
86
111 - - 93.9
87
107 - - 70.4
90
102
3D
3mmzD00 - 47.0
88
101 - - 72.9
89
100 - - 72.1
91
98 - - 20.4
93
97 - - 96.1
92
97 - - 60.5
106
95
3D
4g9bA01 - 80.9
94
94 - - 84.2
95
92 - - 76.8
96
90 - - 77.8
97
87 - - 70.3
98
86 - - 81.8
99
85 - - 73.3
100
84 - - 75.5
102
83
3D
1zs9A01 - 68.7
101
81 - - 88.6
133
5'
3'
81
3D
2jarA01 - 69.6
103
75 - - 9.5
105
75
3D
1rkvB01 - 30.9
104
74 - - 82.0
108
68 - - 67.2
116
67
3D
4knwC01 - 49.7
109
66 - - 56.1
110
65 - - 49.1
111
65 - - 70.9
115
64 - - 91.6
113
64 - - 73.1
112
64 - - 73.0
114
64 - - 72.6
118
64
3D
2x4dB01 - 78.3
117
63 - - 77.8
119
62 - - 85.6
120
61 - - 81.0
123
60
3D
4bkmD02 - 76.4
122
59 - - 72.6
121
59 - - 89.8
168
57
3D
3l8hD00 - 85.3
127
56
3D
1u7pD00 - 81.8
124
55 - - 82.2
125
53 - - 75.5
126
51 - - 80.1
130
50 - - 84.1
129
50 - - 79.6
140
50
3D
5aesB02 - 78.4
128
50 - - 73.1
132
49 - - 65.4
163
49
3D
4bkmD01 - 64.3
131
49 - - 85.2
135
46 - - 80.0
134
46 - - 82.4
137
45 - - 72.4
136
45 - - 70.1
138
45 - - 77.6
141
43 - - 14.2
139
43 - - 27.3
142
41 - - 74.7
143
40 - - 85.1
146
40
3D
4ezeB00 - 5.0
144
39 - - 86.7
145
39 - - 89.3
147
38 - - 74.4
148
37 - - 71.1
151
36 - - 79.8
149
36 - - 76.3
150
36 - - 70.3
152
36 - - 88.4
154
35 - - 82.4
153
35 - - 74.5
156
34 - - 88.0
155
34 - - 80.1
160
33
3D
3qucA01 - 25.7
159
32 - - 92.5
158
32 - - 73.0
157
32 - - 16.1
178
31
3D
3rf6B02 - 75.5
162
31 - - 67.2
161
31 - - 51.5
164
30 - - 71.8
231
30
3D
2ia5L02 - 21.8
166
29 - - 81.8
165
29 - - 87.4
167
29 - - 74.6
169
29 - - 96.7
170
29 - - 98.4
171
28 - - 72.3
182
28
3D
3skyA01 - 77.5
172
28 - - 73.2
173
28 - - 77.4
179
27 - - 87.2
174
27 - - 2.0
176
27 - - 73.0
177
27 - - 91.1
175
27 - - 72.5
184
26 - - 97.5
188
26
3D
5e0oA02 - 73.9
181
26 - - 14.5
180
26 - - 48.7
183
26 - - 87.6
185
25 - - 84.6
195
24
3D
3opxA01 - 55.6
187
24 - - 33.8
186
+2
24 - - 84.1
189
23 - - 78.8
212
23
3D
4i9gB01 - 71.7
191
23 - - 82.9
190
23 - - 84.1
193
23 - - 91.3
192
23 - - 81.7
194
22 - - 75.2
198
21 - - 87.5
223
21
3D
4navD00 - 9.4
197
21 - - 2.5
196
21 - - 8.0
201
20 - - 31.2
216
20
3D
2q4rA01 - 34.3
199
20 - - 57.1
204
20 - - 74.6
202
20 - - 15.2
203
20 - - 87.5
200
20 - - 85.2
208
19 - - 26.1
210
19 - - 71.9
209
19 - - 4.2
206
19 - - 41.0
207
19 - - 77.1
211
19 - - 63.5
205
19 - - 36.4
217
18 - - 2.0
215
18 - - 61.3
220
18 - - 3.1
213
18 - - 19.2
214
18 - - 16.4
224
18
3D
2fi1A01 - 17.4
219
18 - - 71.6
218
18 - - 11.6
221
18 - - 58.8
225
17 - - 52.3
226
17 - - 5.6
222
17 - - 0.0
262
17
3D
2msnA01 - 23.1
227
16 - - 41.0
230
16 - - 32.3
266
16
3D
4i9gB02 - 14.7
235
HAD
16 - - 77.5
232
16 - - 12.8
233
16 - - 6.8
234
16 - - 1.7
229
16 - - 3.4
228
16 - - 81.9
236
15 - - 78.5
237
15 - - 42.6
239
15 - - 73.7
240
HAD superfamily
15 - - 3.6
238
15 - - 14.2
241
14 - - 31.6
248
14 - - 0.0
249
14 - - 13.3
244
14 - - 7.7
243
14 - - 73.5
242
14 - - 78.8
250
14 - - 29.4
246
14 - - 4.3
245
14 - - 61.0
247
14 - - 1.5
254
13 - - 74.1
251
13 - - 44.8
255
13 - - 65.2
252
13 - - 10.7
253
13 - - 19.8
267
12 - - 82.9
265
12 - - 39.9
260
12 - - 0.9
259
12 - - 9.7
258
12 - - 40.9
263
12 - - 48.0
257
HAD
12 - - 87.2
264
12 - - 20.3
256
12 - - 21.8
273
12
3D
2ah5A01 - 15.2
268
12 - - 69.3
261
12 - - 20.3
274
11 - - 86.4
279
11 - - 68.4
281
11 - - 67.0
278
11 - - 11.8
271
11 - - 2.6
275
11 - - 10.6
277
11 - - 22.5
280
11 - - 99.4
270
11 - - 61.1
276
11 - - 0.0
269
11 - - 32.3
272
11 - - 32.6
289
10 - - 40.7
299
10 - - 77.0
294
10 - - 47.5
284
10 - - 72.1
302
10 - - 31.2
291
10 - - 0.0
300
10 - - 49.4
288
10 - - 9.3
298
10 - - 72.5
286
10 - - 14.8
296
10 - - 19.5
301
10 - - 61.8
290
10 - - 20.7
287
10 - - 72.1
308
10
3D
3ef0A01 - 50.3
297
10 - - 17.9
295
10 - - 69.3
285
10 - - 0.0
362
10
3D
2i34B00 - 11.2
292
10 - - 23.3
282
10 - - 21.4
283
10 - - 31.1
293
10 - - 10.2
303
9 - - 37.4
306
9 - - 0.0
307
9 - - 71.4
305
9 - - 0.7
311
9 - - 0.0
310
9 - - 75.2
312
9 - - 63.8
309
9 - - 75.4
313
9 - - 60.9
304
9 - - 0.0
324
8 - - 76.5
314
8 - - 74.7
334
8 - - 70.8
329
8 - - 9.5
319
8 - - 4.3
328
8 - - 23.4
318
8 - - 15.1
331
8 - - 36.8
321
5-phospho-D-ribitylamino
8 - - 7.9
327
8 - - 18.5
317
8 - - 8.1
315
8 - - 36.4
325
8 - - 40.2
330
8 - - 5.9
326
8 - - 28.3
316
8 - - 0.6
320
8 - - 0.9
322
8 - - 1.1
323
8 - - 14.7
332
8 - - 32.6
333
8 - - 78.1
357
7 - - 89.4
339
HAD
7 - - 82.9
355
7 - - 1.4
516
7
3D
5ksdB03 - 31.1
343
7 - - 0.0
356
7 - - 7.8
350
7 - - 27.0
342
7 - - 22.3
352
7 - - 15.2
340
7 - - 5.3
353
7 - - 14.9
346
7 - - 8.2
338
7 - - 54.0
345
7 - - 8.8
347
7 - - 2.8
354
7 - - 4.2
341
7 - - 3.0
336
7 - - 13.7
337
7 - - 5.5
359
7 - - 51.1
360
7 - - 64.0
348
7 - - 0.0
335
7 - - 74.7
349
7 - - 7.3
358
7 - - 41.5
351
7 - - 57.1
344
7 - - 16.2
375
6 - - 9.9
364
6 - - 16.0
380
6 - - 29.0
377
HAD superfamily
6 - - 5.0
370
6 - - 33.8
452
6
3D
3hltC01 - 25.5
369
6 - - 14.0
376
6 - - 5.9
368
6 - - 50.4
373
6 - - 10.2
372
6 - - 18.3
361
6 - - 86.0
367
6 - - 9.8
374
6 - - 7.6
365
6 - - 7.5
366
6 - - 6.9
379
6 - - 0.0
381
6 - - 60.8
363
6 - - 2.5
378
6 - - 64.7
371
6 - - 45.9
396
5 - - 15.0
386
5 - - 39.6
405
5 - - 51.2
390
SerB
5 - - 93.9
397
5 - - 12.8
387
5 - - 77.7
385
5 - - 60.1
400
5 - - 9.2
395
5 - - 16.1
402
5 - - 0.0
403
5 - - 6.8
382
5 - - 9.1
392
5 - - 0.0
393
5 - - 4.1
383
5 - - 0.0
404
5 - - 65.4
399
5 - - 15.1
389
5 - - 44.3
384
5 - - 55.0
394
5 - - 9.1
391
5 - - 6.1
398
5 - - 11.7
388
5 - - 42.2
401
5 - - 0.0
438
4 - - 13.0
445
4 - - 74.6
407
4 - - 39.5
447
4 - - 56.0
421
4 - - 14.3
411
4 - - 78.0
418
4 - - 7.3
428
4 - - 11.1
406
4 - - 0.0
440
4 - - 63.1
453
4 - - 69.9
431
4 - - 0.0
446
4 - - 82.4
443
4 - - 47.3
434
4 - - 29.2
456
4 - - 71.2
450
4 - - 43.2
419
4 - - 15.7
429
4 - - 9.3
442
4 - - 1.1
414
4 - - 5.6
457
4 - - 63.4
424
4 - - 60.0
439
4 - - 12.3
455
4 - - 85.0
432
4 - - 7.0
451
4 - - 61.5
433
4 - - 39.6
444
4 - - 43.0
449
4 - - 73.3
422
4 - - 0.0
412
4 - - 88.2
409
4 - - 62.9
423
4 - - 17.6
413
4 - - 3.1
416
4 - - 15.1
426
4 - - 9.1
437
4 - - 4.8
408
4 - - 77.9
410
4 - - 45.7
420
4 - - 14.2
448
4 - - 36.8
435
4 - - 35.4
417
4 - - 0.0
454
4 - - 72.2
427
4 - - 15.9
441
4 - - 68.9
436
4 - - 2.1
425
4 - - 46.9
415
4 - - 7.5
430
4 - - 14.6
482
3 - - 32.8
520
3 - - 45.6
510
3 - - 30.1
492
3 - - 59.0
508
3 - - 69.0
493
3 - - 7.1
483
3 - - 2.6
461
3 - - 52.5
468
3 - - 8.4
473
3 - - 9.2
515
3 - - 62.4
501
3 - - 2.8
472
3 - - 7.0
517
3 - - 66.8
497
3 - - 4.0
470
3 - - 6.2
487
3 - - 1.6
469
3 - - 5.4
485
3 - - 6.2
504
3 - - 41.0
495
3 - - 1.4
476
3 - - 8.8
513
3 - - 64.8
475
3 - - 75.4
509
3 - - 82.4
496
3 - - 1.5
464
3 - - 38.5
486
3 - - 2.5
512
3 - - 52.7
480
3 - - 0.0
522
3 - - 77.6
490
3 - - 23.6
477
3 - - 0.0
471
3 - - 3.5
519
P-type
3 - - 66.3
498
+
3 - - 13.2
503
3 - - 0.8
488
3 - - 0.0
502
3 - - 11.4
462
3 - - 57.8
458
3 - - 20.2
481
3 - - 5.4
514
3 - - 52.9
491
3 - - 39.5
463
3 - - 40.1
478
3 - - 12.2
511
3 - - 3.9
466
3 - - 77.5
484
3 - - 0.0
521
3 - - 50.4
479
3 - - 4.1
494
3 - - 0.0
505
3 - - 7.3
507
3 - - 20.3
459
3 - - 37.7
460
3 - - 19.6
467
SerB
3 - - 0.0
500
3 - - 6.6
506
3 - - 4.6
499
3 - - 0.0
474
3 - - 9.5
465
3 - - 13.8
489
3 - - 3.3
518
3 - - 42.5
535
2 - - 11.7
548
2 - - 0.0
636
2 - - 4.5
560
2 - - 0.0
559
2 - - 0.0
641
2 - - 0.0
627
2 - - 11.4
654
2 - - 40.3
617
2 - - 41.4
630
2 - - 0.0
537
2 - - 9.0
615
2 - - 34.1
594
2 - - 1.5
579
2 - - 0.0
625
2 - - 0.0
584
2 - - 7.6
526
2 - - 1.4
566
2 - - 12.9
601
2 - - 0.0
608
2 - - 18.3
530
2 - - 0.0
637
2 - - 21.5
589
2 - - 48.6
565
2 - - 8.4
525
2 - - 0.0
574
2 - - 6.2
599
2 - - 0.0
626
2 - - 0.0
616
2 - - 35.3
635
2 - - 4.3
648
2 - - 38.9
536
2 - - 19.4
620
2 - - 0.0
610
2 - - 10.6
541
2 - - 35.6
527
2 - - 10.3
554
2 - - 7.8
567
2 - - 0.0
612
2 - - 22.8
544
2 - - 4.6
622
2 - - 0.0
551
2 - - 6.7
533
2 - - 14.6
649
2 - - 31.0
588
2 - - 40.8
532
2 - - 19.8
613
2 - - 25.3
598
2 - - 5.1
623
2 - - 0.0
609
2 - - 25.3
571
2 - - 40.3
632
2 - - 6.3
578
2 - - 4.1
563
2 - - 0.0
523
2 - - 0.0
591
2 - - 0.0
604
2 - - 0.0
581
2 - - 0.0
558
2 - - 0.0
562
2 - - 5.9
644
2 - - 5.5
633
2 - - 1.6
651
2 - - 38.2
549
2 - - 5.3
624
2 - - 0.0
576
2 - - 7.6
657
2 - - 42.2
595
2 - - 0.0
614
2 - - 33.6
542
2 - - 35.6
529
2 - - 0.0
585
2 - - 9.7
550
2 - - 0.0
569
2 - - 0.0
587
2 - - 11.6
556
2 - - 4.5
570
2 - - 0.0
597
2 - - 8.8
655
2 - - 41.4
534
2 - - 12.7
639
2 - - 7.4
543
2 - - 34.8
577
2 - - 2.8
590
2 - - 3.9
656
2 - - 39.6
555
2 - - 0.0
580
2 - - 10.2
602
2 - - 0.0
634
2 - - 15.9
539
2 - - 32.6
643
2 - - 0.0
524
2 - - 0.0
586
2 - - 13.2
564
2 - - 8.7
557
2 - - 5.5
642
2 - - 0.6
596
2 - - 9.0
629
2 - - 0.0
650
2 - - 31.3
619
2 - - 40.5
575
2 - - 11.3
603
2 - - 0.0
561
2 - - 9.4
606
2 - - 0.0
640
2 - - 0.0
652
2 - - 34.5
547
2 - - 0.0
583
2 - - 0.0
628
2 - - 0.0
593
2 - - 8.8
618
2 - - 10.9
545
2 - - 0.0
592
2 - - 0.0
600
2 - - 1.9
646
2 - - 31.7
538
2 - - 24.6
582
2 - - 0.0
631
2 - - 1.0
653
2 - - 32.9
607
2 - - 0.0
645
2 - - 0.0
546
2 - - 3.3
572
2 - - 5.4
638
2 - - 9.8
553
2 - - 0.0
531
2 - - 0.0
611
2 - - 22.8
540
2 - - 16.9
621
2 - - 11.4
552
2 - - 0.0
647
2 - - 31.4
605
2 - - 0.0
573
2 - - 4.3
528
2 - - 3.0
568
2 - - 0.0
860
1 - - 0.0
859
1 - - 0.0
810
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