The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 98: Protein arginine N-methyltransferase 2 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 35 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P55345 (/IPI) P55345 (/IPI) Q9R144 (/IPI) |
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Histone-arginine N-methyltransferase activity GO:0008469
Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
|
2 | P55345 (/ISS) P55345 (/ISS) |
Protein-arginine N-methyltransferase activity GO:0016274
Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
|
2 | P55345 (/ISS) P55345 (/ISS) |
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
2 | P55345 (/IPI) P55345 (/IPI) |
Progesterone receptor binding GO:0033142
Interacting selectively and non-covalently with a progesterone receptor.
|
2 | P55345 (/IPI) P55345 (/IPI) |
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P55345 (/IPI) P55345 (/IPI) |
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
|
2 | P55345 (/IPI) P55345 (/IPI) |
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
|
2 | P55345 (/IPI) P55345 (/IPI) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | P55345 (/ISS) P55345 (/ISS) |
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
|
2 | P55345 (/IPI) P55345 (/IPI) |
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
2 | P55345 (/IPI) P55345 (/IPI) |
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q9R144 (/ISO) |
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
|
1 | Q9R144 (/IPI) |
Histone-arginine N-methyltransferase activity GO:0008469
Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
|
1 | Q9R144 (/IDA) |
Protein-arginine N-methyltransferase activity GO:0016274
Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
|
1 | Q9R144 (/IMP) |
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
1 | Q9R144 (/ISO) |
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
1 | Q9R144 (/ISS) |
Progesterone receptor binding GO:0033142
Interacting selectively and non-covalently with a progesterone receptor.
|
1 | Q9R144 (/ISO) |
Progesterone receptor binding GO:0033142
Interacting selectively and non-covalently with a progesterone receptor.
|
1 | Q9R144 (/ISS) |
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
|
1 | Q9R144 (/ISO) |
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
|
1 | Q9R144 (/ISS) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q9R144 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q9R144 (/ISS) |
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
|
1 | Q9R144 (/ISO) |
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
|
1 | Q9R144 (/ISS) |
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
|
1 | Q9R144 (/ISO) |
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
|
1 | Q9R144 (/ISS) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q9R144 (/IPI) |
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
|
1 | Q9R144 (/ISO) |
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
|
1 | Q9R144 (/ISS) |
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
1 | Q9R144 (/ISO) |
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
1 | Q9R144 (/ISS) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
|
3 | P55345 (/IDA) P55345 (/IDA) Q9R144 (/IDA) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | P55345 (/IDA) P55345 (/IDA) Q9R144 (/IDA) |
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
|
2 | P55345 (/TAS) P55345 (/TAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | P55345 (/TAS) P55345 (/TAS) |
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
|
2 | P55345 (/ISS) P55345 (/ISS) |
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | P55345 (/IGI) P55345 (/IGI) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Developmental cell growth GO:0048588
The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
|
2 | P55345 (/ISS) P55345 (/ISS) |
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
2 | P55345 (/ISS) P55345 (/ISS) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | Q9R144 (/IDA) |
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
|
1 | Q9R144 (/ISO) |
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
1 | Q9R144 (/ISO) |
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
|
1 | Q9R144 (/NAS) |
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
|
1 | Q9R144 (/NAS) |
Regulation of tyrosine phosphorylation of STAT protein GO:0042509
Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q9R144 (/NAS) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q9R144 (/ISO) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q9R144 (/ISS) |
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | Q9R144 (/IMP) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9R144 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9R144 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9R144 (/ISS) |
Developmental cell growth GO:0048588
The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
|
1 | Q9R144 (/IMP) |
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
1 | Q9R144 (/ISO) |
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
1 | Q9R144 (/ISS) |
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
1 | Q9R144 (/IMP) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | A0A0S2Z3N3 (/IDA) A0A0S2Z3N3 (/IDA) P55345 (/IDA) P55345 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A0A0S2Z3N3 (/IDA) A0A0S2Z3N3 (/IDA) P55345 (/IDA) P55345 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P55345 (/TAS) P55345 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P55345 (/IDA) P55345 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9R144 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9R144 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9R144 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9R144 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9R144 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9R144 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9R144 (/ISS) |