The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 65: adapter molecule crk isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 37 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
45 P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI)
(35 more)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
38 P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI)
(28 more)
Protein phosphorylated amino acid binding GO:0045309
Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein.
26 P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA)
(16 more)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
26 P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI)
(16 more)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
25 P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI)
(15 more)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
24 P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA)
(14 more)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
24 P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI)
(14 more)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
24 P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI)
(14 more)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
24 P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA)
(14 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
14 P46109 (/HDA) P46109 (/HDA) P46109 (/HDA) P46109 (/HDA) P46109 (/HDA) P46109 (/HDA) P46109 (/HDA) P46109 (/HDA) P46109 (/HDA) P46109 (/HDA)
(4 more)
Showing 1 to 10 of 37 entries

There are 129 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
38 P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS)
(28 more)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
38 P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS)
(28 more)
Positive regulation of substrate adhesion-dependent cell spreading GO:1900026
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
38 P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP)
(28 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
24 P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS)
(14 more)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
24 P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP)
(14 more)
Regulation of signal transduction GO:0009966
Any process that modulates the frequency, rate or extent of signal transduction.
24 P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA)
(14 more)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
24 P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA)
(14 more)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
24 P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS)
(14 more)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
24 P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA) P46108 (/IDA)
(14 more)
Regulation of protein binding GO:0043393
Any process that modulates the frequency, rate or extent of protein binding.
24 P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP) P46108 (/IMP)
(14 more)
Showing 1 to 10 of 129 entries

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
41 P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS)
(31 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
24 P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS) P46108 (/TAS)
(14 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
24 P46108 (/IC) P46108 (/IC) P46108 (/IC) P46108 (/IC) P46108 (/IC) P46108 (/IC) P46108 (/IC) P46108 (/IC) P46108 (/IC) P46108 (/IC)
(14 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
24 P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI) P46108 (/IPI)
(14 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
24 P46108 (/HDA) P46108 (/HDA) P46108 (/HDA) P46108 (/HDA) P46108 (/HDA) P46108 (/HDA) P46108 (/HDA) P46108 (/HDA) P46108 (/HDA) P46108 (/HDA)
(14 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
14 P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA) P46109 (/IDA)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P47941 (/ISO) P47941 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P47941 (/ISO) P47941 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P47941 (/ISO) P47941 (/ISO)
Showing 1 to 10 of 20 entries
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