The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 61: Cytoplasmic protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 23 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
38 |
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
E7ERP6 (/IPI)
(28 more) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
23 |
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
(13 more) |
|
Cytoskeletal adaptor activity GO:0008093
The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way.
|
23 |
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
(13 more) |
|
Receptor signaling complex adaptor activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
|
23 |
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
(13 more) |
|
Eukaryotic initiation factor eIF2 binding GO:0071074
Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.
|
15 |
B2RZ33 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
(5 more) |
|
Protein kinase inhibitor activity GO:0004860
Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
|
13 |
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
(3 more) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
13 |
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
(3 more) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
13 |
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
(3 more) |
|
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
13 |
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
P16333 (/IC)
(3 more) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
13 |
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
P16333 (/IPI)
(3 more) |
Showing 1 to 10 of 23 entries
There are 65 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signal complex assembly GO:0007172
The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.
|
23 |
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
(13 more) |
|
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
|
23 |
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
(13 more) |
|
Negative regulation of peptidyl-serine phosphorylation GO:0033137
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
23 |
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
(13 more) |
|
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
23 |
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
O43639 (/IMP)
(13 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
23 |
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
(13 more) |
|
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
23 |
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
(13 more) |
|
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation GO:1903912
Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation.
|
23 |
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
(13 more) |
|
Positive regulation of translation in response to endoplasmic reticulum stress GO:0036493
Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.
|
13 |
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
(3 more) |
|
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
|
13 |
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
(3 more) |
|
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
13 |
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
P16333 (/IMP)
(3 more) |
Showing 1 to 10 of 65 entries
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
24 |
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
(14 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
24 |
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
O43639 (/TAS)
(14 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
23 |
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
O43639 (/NAS)
(13 more) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
23 |
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
O43639 (/IDA)
(13 more) |
|
Protein phosphatase type 1 complex GO:0000164
A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.
|
13 |
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
(3 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
13 |
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
(3 more) |
|
Ribosome GO:0005840
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
|
13 |
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
P16333 (/IDA)
(3 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
13 |
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
P16333 (/TAS)
(3 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O55033 (/ISO) Q99M51 (/ISO) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | O55033 (/ISO) Q99M51 (/ISO) |
Showing 1 to 10 of 19 entries
