The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 139: Hematopoietic cell-specific Lyn substrate 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P14317 (/IPI) P49710 (/IPI) |
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
1 | P14317 (/IPI) |
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
1 | P49710 (/ISO) |
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
|
1 | P49710 (/IDA) |
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
|
1 | P49710 (/IPI) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P14317 (/IPI) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P49710 (/ISO) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | P49710 (/IPI) |
There are 35 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
4 | P14317 (/ISS) Q3SYW3 (/ISS) Q4R7C6 (/ISS) Q68FX4 (/ISS) |
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
4 | P14317 (/ISS) Q3SYW3 (/ISS) Q4R7C6 (/ISS) Q68FX4 (/ISS) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
4 | P14317 (/ISS) Q3SYW3 (/ISS) Q4R7C6 (/ISS) Q68FX4 (/ISS) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
4 | P14317 (/ISS) Q3SYW3 (/ISS) Q4R7C6 (/ISS) Q68FX4 (/ISS) |
Positive regulation of granulocyte differentiation GO:0030854
Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
|
2 | P14317 (/IMP) P49710 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P14317 (/IMP) P49710 (/IMP) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P49710 (/IMP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P14317 (/TAS) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P49710 (/IMP) |
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | P49710 (/IDA) |
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
1 | P14317 (/IMP) |
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
1 | P49710 (/ISO) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | P49710 (/IMP) |
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
|
1 | P14317 (/IMP) |
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
|
1 | P49710 (/ISO) |
Positive regulation of granulocyte differentiation GO:0030854
Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
|
1 | P49710 (/ISO) |
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
1 | P14317 (/IMP) |
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
1 | P49710 (/ISO) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | P14317 (/TAS) |
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
1 | P14317 (/IMP) |
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
1 | P49710 (/ISO) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | P49710 (/IMP) |
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
|
1 | P49710 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P49710 (/ISO) |
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | P14317 (/IMP) |
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | P49710 (/ISO) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P14317 (/IMP) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P49710 (/ISO) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | P14317 (/IMP) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | P49710 (/ISO) |
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | P14317 (/IMP) |
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | P49710 (/ISO) |
Negative regulation of leukocyte apoptotic process GO:2000107
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.
|
1 | P14317 (/IMP) |
Negative regulation of leukocyte apoptotic process GO:2000107
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.
|
1 | P49710 (/ISO) |
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
|
1 | P14317 (/IC) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P14317 (/ISS) Q3SYW3 (/ISS) Q4R7C6 (/ISS) Q68FX4 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | P14317 (/ISS) Q3SYW3 (/ISS) Q4R7C6 (/ISS) Q68FX4 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P14317 (/IDA) P49710 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P14317 (/IDA) P49710 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | E7EVW7 (/IDA) P14317 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | E7EVW7 (/IDA) P14317 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P49710 (/ISO) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | P14317 (/IDA) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | P49710 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P49710 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P49710 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P49710 (/ISO) |