The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 1: Sorbin and SH3 domain-containing protein 1 isoform...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 29 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
A1Z866 (/IPI)
O60504 (/IPI)
O94875 (/IPI)
Q3UTJ2 (/IPI)
Q62417 (/IPI)
Q69ZI1 (/IPI)
Q6NRD3 (/IPI)
Q71F54 (/IPI)
Q7Z6J0 (/IPI)
Q8K0M3 (/IPI)
(3 more) |
MAP-kinase scaffold activity GO:0005078
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
|
8 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q7Z6J0 (/ISS) |
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
8 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q8C120 (/ISS) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | Q7K4D1 (/IDA) Q9NHP2 (/IDA) |
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
|
2 | Q62417 (/IDA) Q9BX66 (/IDA) |
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
|
2 | O60504 (/TAS) O94875 (/TAS) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | Q62417 (/IPI) Q9R1Z8 (/IPI) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q7K4D1 (/ISM) Q9NHP2 (/ISM) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | Q7K4D1 (/IPI) Q9NHP2 (/IPI) |
Receptor signaling complex adaptor activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
|
2 | Q7K4D1 (/NAS) Q9NHP2 (/NAS) |
Showing 1 to 10 of 29 entries
There are 70 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
24 |
A0A0B4K6W0 (/IMP)
A0A0B4K7L3 (/IMP)
A0A0B4K7W2 (/IMP)
A0A0B4KEH7 (/IMP)
A0A0B4KEJ6 (/IMP)
A1Z866 (/IMP)
A1Z867 (/IMP)
A1Z869 (/IMP)
A1Z870 (/IMP)
A1Z871 (/IMP)
(14 more) |
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
|
24 |
A0A0B4K6W0 (/IMP)
A0A0B4K7L3 (/IMP)
A0A0B4K7W2 (/IMP)
A0A0B4KEH7 (/IMP)
A0A0B4KEJ6 (/IMP)
A1Z866 (/IMP)
A1Z867 (/IMP)
A1Z869 (/IMP)
A1Z870 (/IMP)
A1Z871 (/IMP)
(14 more) |
Sensory perception of mechanical stimulus GO:0050954
The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
|
24 |
A0A0B4K6W0 (/IMP)
A0A0B4K7L3 (/IMP)
A0A0B4K7W2 (/IMP)
A0A0B4KEH7 (/IMP)
A0A0B4KEJ6 (/IMP)
A1Z866 (/IMP)
A1Z867 (/IMP)
A1Z869 (/IMP)
A1Z870 (/IMP)
A1Z871 (/IMP)
(14 more) |
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
9 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q7Z6J0 (/ISS) Q8C120 (/ISS) |
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
9 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q69ZI1 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q8C120 (/ISS) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
8 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q7Z6J0 (/ISS) |
Regulation of CD4-positive, alpha-beta T cell differentiation GO:0043370
Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
|
8 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q7Z6J0 (/ISS) |
Regulation of CD8-positive, alpha-beta T cell proliferation GO:2000564
Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.
|
8 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q7Z6J0 (/ISS) |
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
2 | Q7K4D1 (/IMP) Q9NHP2 (/IMP) |
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
|
2 | O60504 (/TAS) Q9BX66 (/TAS) |
Showing 1 to 10 of 70 entries
There are 44 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
8 | A5D7F8 (/ISS) A5D8S5 (/ISS) Q28E95 (/ISS) Q28E95 (/ISS) Q5RBR0 (/ISS) Q6NRD3 (/ISS) Q71F54 (/ISS) Q7Z6J0 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q62417 (/IDA) Q9BX66 (/IDA) Q9R1Z8 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q7K4D1 (/ISS) Q9BX66 (/ISS) Q9NHP2 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q62417 (/IDA) Q7Z6J0 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O60504 (/TAS) Q9BX66 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q3UTJ2 (/IDA) Q9BX66 (/IDA) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | Q9BX66 (/IDA) Q9R1Z8 (/IDA) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
2 | Q3UTJ2 (/IDA) Q62417 (/IDA) |
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | Q62417 (/IDA) |
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | Q9BX66 (/ISS) |
Showing 1 to 10 of 44 entries