The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Tumor Necrosis Factor Receptor, subunit A, domain 2
".
FunFam 65: TNF receptor superfamily member 14
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q71F55 (/IPI) Q80WM9 (/IPI) |
|
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
|
1 | Q71F55 (/IPI) |
|
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
|
1 | Q80WM9 (/ISO) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q80WM9 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of cytokine secretion involved in immune response GO:0002741
Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response.
|
1 | Q80WM9 (/IMP) |
|
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
|
1 | Q80WM9 (/ISO) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
1 | Q71F55 (/IMP) |
|
Negative regulation of alpha-beta T cell proliferation GO:0046642
Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation.
|
1 | Q80WM9 (/IDA) |
|
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | Q80WM9 (/IDA) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | Q80WM9 (/IMP) |
|
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
1 | Q80WM9 (/IMP) |
|
Negative regulation of adaptive immune memory response GO:1905675
Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response.
|
1 | Q80WM9 (/ISO) |
|
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
|
1 | Q80WM9 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q80WM9 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q80WM9 (/TAS) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q80WM9 (/IDA) |