The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tumor Necrosis Factor Receptor, subunit A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36: Tumor necrosis factor receptor superfamily member ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P20333 (/IPI) P25119 (/IPI) P25119 (/IPI)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
2 P25119 (/IPI) P25119 (/IPI)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
2 P25119 (/ISO) P25119 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 P25119 (/ISO) P25119 (/ISO)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
2 P25119 (/ISO) P25119 (/ISO)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
1 Q80WY6 (/IDA)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
1 P20333 (/TAS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P20333 (/IPI)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
1 P20333 (/IPI)

There are 56 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of T cell cytokine production GO:0002724
Any process that modulates the frequency, rate, or extent of T cell cytokine production.
2 P25119 (/IMP) P25119 (/IMP)
Regulation of cytokine secretion involved in immune response GO:0002739
Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response.
2 P25119 (/IGI) P25119 (/IGI)
Aortic valve development GO:0003176
The progression of the aortic valve over time, from its formation to the mature structure.
2 P25119 (/IGI) P25119 (/IGI)
Pulmonary valve development GO:0003177
The progression of the pulmonary valve over time, from its formation to the mature structure.
2 P25119 (/IGI) P25119 (/IGI)
Negative regulation of extracellular matrix constituent secretion GO:0003332
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
2 P25119 (/IGI) P25119 (/IGI)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 P25119 (/IMP) P25119 (/IMP)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 P25119 (/ISO) P25119 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P25119 (/IMP) P25119 (/IMP)
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
2 P25119 (/IMP) P25119 (/IMP)
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
2 P25119 (/IGI) P25119 (/IGI)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
2 P25119 (/IGI) P25119 (/IGI)
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
2 P25119 (/IMP) P25119 (/IMP)
Regulation of T cell proliferation GO:0042129
Any process that modulates the frequency, rate or extent of T cell proliferation.
2 P25119 (/IMP) P25119 (/IMP)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
2 P25119 (/IMP) P25119 (/IMP)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
2 P25119 (/IMP) P25119 (/IMP)
RNA destabilization GO:0050779
Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes.
2 P25119 (/IMP) P25119 (/IMP)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
2 P25119 (/ISO) P25119 (/ISO)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2 P25119 (/IMP) P25119 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P25119 (/ISO) P25119 (/ISO)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2 P25119 (/IMP) P25119 (/IMP)
Regulation of neuroinflammatory response GO:0150077
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
2 P25119 (/IGI) P25119 (/IGI)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
2 P25119 (/IMP) P25119 (/IMP)
Glial cell-neuron signaling GO:0150098
Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.
2 P25119 (/IMP) P25119 (/IMP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
2 P25119 (/IMP) P25119 (/IMP)
Positive regulation of apoptotic process involved in morphogenesis GO:1902339
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.
2 P25119 (/IGI) P25119 (/IGI)
Regulation of RNA biosynthetic process GO:2001141
Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
2 P25119 (/IMP) P25119 (/IMP)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
1 A0A0B5JS36 (/IGI)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
1 A0A0B5JS36 (/IMP)
Regulation of T cell cytokine production GO:0002724
Any process that modulates the frequency, rate, or extent of T cell cytokine production.
1 P20333 (/ISS)
Regulation of cytokine secretion involved in immune response GO:0002739
Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response.
1 P20333 (/ISS)
Aortic valve development GO:0003176
The progression of the aortic valve over time, from its formation to the mature structure.
1 P20333 (/ISS)
Pulmonary valve development GO:0003177
The progression of the pulmonary valve over time, from its formation to the mature structure.
1 P20333 (/ISS)
Negative regulation of extracellular matrix constituent secretion GO:0003332
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
1 P20333 (/ISS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 Q80WY6 (/IDA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q80WY6 (/IEP)
Establishment of endothelial blood-brain barrier GO:0014045
Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
1 A0A0B5JS36 (/IGI)
Establishment of endothelial blood-brain barrier GO:0014045
Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
1 A0A0B5JS36 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P20333 (/TAS)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 P20333 (/ISS)
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 P20333 (/ISS)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q80WY6 (/IEP)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P20333 (/TAS)
Regulation of T cell proliferation GO:0042129
Any process that modulates the frequency, rate or extent of T cell proliferation.
1 P20333 (/ISS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P20333 (/TAS)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
1 P20333 (/ISS)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
1 P20333 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P20333 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P20333 (/IMP)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q80WY6 (/IEP)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 Q80WY6 (/IEP)
Regulation of neuroinflammatory response GO:0150077
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
1 P20333 (/ISS)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
1 P20333 (/ISS)
Glial cell-neuron signaling GO:0150098
Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.
1 P20333 (/ISS)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P20333 (/ISS)
Positive regulation of apoptotic process involved in morphogenesis GO:1902339
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.
1 P20333 (/ISS)
Regulation of RNA biosynthetic process GO:2001141
Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
1 P20333 (/ISS)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 P25119 (/IDA) P25119 (/IDA) Q80WY6 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
3 P20333 (/IDA) P25119 (/IDA) P25119 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P25119 (/ISO) P25119 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P25119 (/ISO) P25119 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 P25119 (/ISO) P25119 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P25119 (/ISO) P25119 (/ISO)
Varicosity GO:0043196
Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.
2 P25119 (/ISO) P25119 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 P25119 (/ISO) P25119 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 P25119 (/ISO) P25119 (/ISO)
Tumor necrosis factor receptor superfamily complex GO:0002947
A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.
1 P20333 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q80WY6 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P20333 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P20333 (/TAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q80WY6 (/IDA)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 P20333 (/TAS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q80WY6 (/IDA)
Varicosity GO:0043196
Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.
1 Q80WY6 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q80WY6 (/IDA)
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