The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tumor Necrosis Factor Receptor, subunit A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: Tumor necrosis factor receptor superfamily member ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O19131 (/IPI) P19438 (/IPI) P22934 (/IPI) P25118 (/IPI) P25118 (/IPI)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
3 P22934 (/IMP) P25118 (/IMP) P25118 (/IMP)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
3 O19131 (/ISS) P22934 (/ISS) P50555 (/ISS)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
3 P19438 (/TAS) P25118 (/TAS) P25118 (/TAS)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P25118 (/ISO) P25118 (/ISO)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
2 P25118 (/IPI) P25118 (/IPI)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
2 P25118 (/ISO) P25118 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P25118 (/ISO) P25118 (/ISO)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
2 P19438 (/IPI) P22934 (/IPI)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
2 P25118 (/ISO) P25118 (/ISO)
Showing 1 to 10 of 13 entries

There are 70 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
3 O19131 (/ISS) P22934 (/ISS) P50555 (/ISS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 O19131 (/ISS) P22934 (/ISS) P50555 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P19438 (/IMP) P25118 (/IMP) P25118 (/IMP)
Aortic valve development GO:0003176
The progression of the aortic valve over time, from its formation to the mature structure.
2 P25118 (/IGI) P25118 (/IGI)
Pulmonary valve development GO:0003177
The progression of the pulmonary valve over time, from its formation to the mature structure.
2 P25118 (/IGI) P25118 (/IGI)
Negative regulation of extracellular matrix constituent secretion GO:0003332
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
2 P25118 (/IGI) P25118 (/IGI)
Showing 1 to 10 of 70 entries

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
5 O19131 (/ISS) P22934 (/ISS) P25118 (/ISS) P25118 (/ISS) P50555 (/ISS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 P19438 (/IDA) P22934 (/IDA) P25118 (/IDA) P25118 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P19438 (/TAS) P25118 (/TAS) P25118 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 P22934 (/IDA) P25118 (/IDA) P25118 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 P25118 (/ISO) P25118 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P19438 (/IDA) P22934 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P25118 (/ISO) P25118 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P25118 (/ISO) P25118 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P25118 (/ISO) P25118 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P25118 (/ISO) P25118 (/ISO)
Showing 1 to 10 of 29 entries
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