The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Metastasis suppressor 1, isoform CRA_eBrain-specific angiogenesis inhibitor 1-associated protein 2brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2SC:2Tyrosine-protein kinaseGEM-interacting protein isoform X1Rho GTPase activatorSuppressor of yeast profilin deletionSC:3arfaptin-2 isoform X1Sphingolipid long chain base-responsive pil1Bridging integrator 1, isoform CRA_eAmphiphysin isoform 2Bridging integrator 2SC:4FCH domain only protein 2Protein kinase C and casein kinase substrate in neurons protein 1SC:5Putative DCC-interacting protein 13-beta isoform 2Sorting nexinSorting nexinDCC-interacting protein 13-alpha isoform X2Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1SC:6Sorting nexin 2Rho GTPase-activating protein 26Formin-binding protein 1-like isoform 1Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1SLIT-ROBO Rho GTPase-activating protein 1 isoform 2Sorting nexinProtein kinase C and casein kinase substrate in neurons 2Protein hob3, variantIslet cell autoantigen 1, 69kDaendophilin-B2 isoform X1Rho GTPase activating protein 44rho GTPase-activating protein 17 isoform X1SLIT-ROBO Rho GTPase activating protein 3Endophilin-A2 isoform 1Sorting nexin 3 proteinInteracting with PRKCAgrowth arrest-specific protein 7 isoform X2arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2FCH and double SH3 domains protein 2dynamin-binding protein isoform X1Bridging integrator 3 homologTyrosine-protein kinaseSorting nexin 4Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3Proline-serine-threonine phosphatase interacting protein 1Rho GTPase activating protein 29FCH and double SH3 domains proteinF-BAR and double SH3 domains protein 1Vacuolar targeting protein Atg24Brain-specific angiogenesis inhibitor 1-associated protein 2-like 1Sorting nexin 1Cell division control proteinVacuolar protein sorting-associated protein 17protein FAM92A isoform X1BAR adaptor protein RVS167Sorting nexin 8RhoGAP and Fes/CIP4 domain proteinARF GTPase activator (Csx2)Rho GTPase activating protein 4SH3 domain-binding protein 1Proline-serine-threonine phosphatase interacting protein 2Uncharacterized protein, isoform FRho guanine nucleotide exchange factor 37Rho GTPase activating protein 45Rho GTPase activating protein 4bActin polymerization protein Bzz1Rho guanine nucleotide exchange factor 38Tyrosine-protein kinaseUncharacterized protein, isoform BMetastasis suppressor protein 1NOSTRIN isoform 1Islet cell autoantigenNostrin, isoform DUncharacterized protein, isoform CUncharacterized protein, isoform USorting nexin MVP1RhoGAP and Fes/CIP4 domain proteinRho GTPase-activating protein 42Related to IVY1-phospholipid-binding proteinRho GTPase activating protein 42SH3 domain-containing protein 1Slm1pTranscription factor SipA3ADP-ribosylation factor GTPase-activating protein AGD3Sorting nexin 2BEndophilin B, isoform CRho guanyl nucleotide exchange factor, putativeBAI1-associated protein 2-like 2bPredicted proteinRho GTPase-activating protein 10Rho guanyl nucleotide exchange factorIvy1pBAI1 associated protein 2Snx4pSorting nexin 1Gvp36pRho GTPase-activating protein 92BSLIT-ROBO Rho GTPase-activating 2 proteinHydroxyproline-rich glycoprotein family proteinUnplaced genomic scaffold supercont2.2, whole genome shotgun sequenceVacuolar protein sorting-associated protein 17FCH and double SH3 domains protein 2 isoform X3Rho guanine nucleotide exchange factor 37Unplaced genomic scaffold supercont2.8, whole genome shotgun sequenceF-BAR and double SH3 domains protein 2 isoform X6WGS project CABT00000000 data, contig 2.23Hof1pUnplaced genomic scaffold supercont1.20, whole genome shotgun sequenceYsp1pAtg20pSlit-Robo GAP homologRho-GTPase-activating protein RGD2Rho-GTPase-activating protein RGD2Sorting nexinYPR148C-like proteinYKR078W-like proteinAtg20pFormin-binding protein 1-likePutative Dynamin-binding proteinSynDaPiN (Synaptic dynamin binding protein) homologUnplaced genomic scaffold supercont1.83, whole genome shotgun sequenceUnplaced genomic scaffold supercont1.126, whole genome shotgun sequenceYPR115W-like proteinGTPase activating protein, putativeProtein CBG22463Related to SYP1/YCR030CEndophilin-A homologPutative phosphoinositide-binding proteinSIP3p Transcription cofactorProtein CBG03954FCH domain Only (FCH stands for Fes/CIP4 homology domain)Islet cell autoantigenVariant sh3 domain containing proteinVariant sh3 domain containing proteinRho GTPase Activating proteinSLIT-ROBO Rho GTPase-activating protein 2Glucosamine 6-phosphate N-acetyltransferase, putativeGTPase activating protein, putativeUncharacterized proteinUncharacterized proteinChromosome 9, whole genome shotgun sequenceUncharacterized proteinVariant sh3 domain containing proteinWGS project CABT00000000 data, contig 2.6Rho GTPase-activating protein 92BProline-serine-threonine phosphatase-interacting protein 1bUncharacterized proteinUncharacterized proteinGlucosamine 6-phosphate N-acetyltransferaseProtein CBG09025Unplaced genomic scaffold supercont1.21, whole genome shotgun sequenceGH04442pArp2/3 complex-activating protein ricka, putativeUncharacterized proteinFormin 2,3 and collagen domain containing proteinUncharacterized proteinSorting nexin-2Uncharacterized proteinSLIT-ROBO Rho GTPase-activating protein 2 isoform X8Uncharacterized proteinBridging integrator 2Zgc:158689ADP-ribosylation factor-interacting protein 2aHypothetical_protein_-_conservedRho GTPase-activating protein 17AGAP009727-PAPutative Sip3 proteinBAI1-associated protein 2Sorting NeXinSorting nexin 7Rgd3pRgd3pRho GTPase-activating protein 10Protein kinase C and casein kinase substrate in neurons 3Uncharacterized proteinMeiotically up-regulated gene 137 proteinSH3 domain signalling protein (AFU_orthologue AFUA_5G07670)Uncharacterized proteinUncharacterized proteinCell division control protein, putativesorting nexin-6Vacuolar protein sorting-associated protein 17Vacuolar protein sorting-associated protein 17Autophagy-related protein 24Sorting nexin, putativeUncharacterized proteinUncharacterized proteinTranscription modulator, putativeYALI0E05489pUncharacterized proteinDip13 beta, putativeUncharacterized proteinUncharacterized proteinYALI0D07524pYALI0F13673pDynamin-binding proteinAge1pAaceriAFR725CpYALI0B15686pYALI0B15686pUncharacterized proteinUncharacterized proteingrowth arrest-specific protein 7Uncharacterized proteinrho GTPase-activating protein 26Uncharacterized proteinUncharacterized proteinYALI0F01694pYALI0C03245pBridging integrator 3-like proteinarfaptin-2-like isoform X2Bridging integrator 1bUncharacterized proteinChromosome 13 SCAF14555, whole genome shotgun sequenceGRAFUncharacterized proteinFcho-1Uncharacterized proteinAEL147WpUncharacterized proteinSH3 and F-BAR domain-containing protein DDB_G0274695SH3 domain-containing proteinUncharacterized proteinF-BAR and double SH3 domains protein 2Uncharacterized proteinYALI0F19778pBrain-specific angiogenesis inhibitor 1-associated protein 2Uncharacterized proteinProtein kinase C and casein kinase substrate in neurons protein 1Sdpn-1AaceriABR082WpUncharacterized proteinUncharacterized proteinUncharacterized proteinYALI0E13904pUncharacterized proteinRho GTPase-activating protein gacPMental retardation GTPase activating protein homolog 4Uncharacterized proteinUncharacterized proteinrho GTPase-activating protein 17 isoform X1Nitric oxide synthase-traffickingUncharacterized proteinIslet cell autoantigen, putativeRho-GTPase-activating protein 8Uncharacterized proteinUncharacterized proteinRho GTPase-activating protein 4Chromosome 16, whole genome shotgun sequenceProbable Rho-GTPase-activating protein 9Uncharacterized proteinChromosome 1, whole genome shotgun sequenceUncharacterized proteinChromosome 19, whole genome shotgun sequenceInositol-pentakisphosphate 2-kinaseUncharacterized proteinRho-GTPase-activating protein 8BAR domaincontaining proteinArfGAP with SH3 domain, ankyrin repeat and PH domain 3Uncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinRho GTPase-activating protein 26-like ProteinUncharacterized proteinUncharacterized proteinUncharacterized proteinLD28528pZgc:158689Uncharacterized proteinUncharacterized proteinUncharacterized proteinProtein kinase C alpha binding protein, putativeZgc:158689Uncharacterized proteinUncharacterized proteinDip13 beta, putativeUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinFES proto-oncogene, tyrosine kinaseUncharacterized proteinProtein kinase C and casein kinase substrate in neurons 1aPredicted proteinBridging integrator 2bUncharacterized proteinAsap2a proteinArfGAP with SH3 domain, ankyrin repeat and PH domain 3Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinMeiotically up-regulated gene 64 proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinBAI1-associated protein 2bUncharacterized proteinUncharacterized proteinDDEFL1 proteinVariant SH3 domain containing proteinUncharacterized proteinBridging integrator, putativeAGAP001369-PAUbp4-interactor sfp47Uncharacterized proteinInsulin receptor tyrosine kinase substrate, putativeUncharacterized proteinPredicted proteinSH3-domain GRB2-like 3bUncharacterized proteinUncharacterized proteinSorting nexin-41Uncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinRho GTPase-activating protein 44Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinAFR651WpUncharacterized PH domain-containing protein C19A8.02Uncharacterized proteinUncharacterized proteinUncharacterized protein
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FunFam 113: Atg20p

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q07528 (/IPI) Q07528 (/IPI)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
2 Q07528 (/IDA) Q07528 (/IDA)
Showing 1 to 2 of 2 entries

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Autophagy of mitochondrion GO:0000422
The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
2 Q07528 (/IMP) Q07528 (/IMP)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
2 Q07528 (/IMP) Q07528 (/IMP)
Protein localization by the Cvt pathway GO:0032258
A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.
2 Q07528 (/IMP) Q07528 (/IMP)
Early endosome to Golgi transport GO:0034498
The directed movement of substances from early endosomes to the Golgi.
2 Q07528 (/IGI) Q07528 (/IGI)
Early endosome to Golgi transport GO:0034498
The directed movement of substances from early endosomes to the Golgi.
2 Q07528 (/IMP) Q07528 (/IMP)
Early endosome to Golgi transport GO:0034498
The directed movement of substances from early endosomes to the Golgi.
2 Q07528 (/IPI) Q07528 (/IPI)
Showing 1 to 6 of 6 entries

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Phagophore assembly site GO:0000407
Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
2 Q07528 (/IDA) Q07528 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 Q07528 (/IDA) Q07528 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 Q07528 (/IDA) Q07528 (/IDA)
Showing 1 to 3 of 3 entries
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