The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Retinoid X Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Estrogen receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 91 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
31 A0A068EUA1 (/ISS) A0A087R654 (/ISS) A0A087R654 (/ISS) A0A091EZL1 (/ISS) A0A091G8M1 (/ISS) A0A091I716 (/ISS) A0A091MIX0 (/ISS) A0A091P4V0 (/ISS) A0A091V5E3 (/ISS) A0A091W4K7 (/ISS)
(21 more)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
30 O08537 (/ISS) O08537 (/ISS) O13012 (/ISS) O93511 (/ISS) P03372 (/ISS) P03372 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) P57781 (/ISS)
(20 more)
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
22 A0A060X747 (/IDA) B8JJL3 (/IDA) B8JJL4 (/IDA) E5L8C9 (/IDA) P03372 (/IDA) P03372 (/IDA) P06211 (/IDA) P06212 (/IDA) P16058 (/IDA) P57717 (/IDA)
(12 more)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
17 B8JJL3 (/IDA) B8JJL4 (/IDA) P03372 (/IDA) P03372 (/IDA) P19785 (/IDA) P19785 (/IDA) P57717 (/IDA) Q5PR29 (/IDA) Q7ZU32 (/IDA) Q8AV62 (/IDA)
(7 more)
Steroid hormone binding GO:1990239
Interacting selectively and non-covalently with a steroid hormone.
14 B8JJL3 (/IDA) B8JJL4 (/IDA) P16058 (/IDA) P57717 (/IDA) P57782 (/IDA) Q5PR29 (/IDA) Q7ZU32 (/IDA) Q8AV62 (/IDA) Q90WS8 (/IDA) Q90WS9 (/IDA)
(4 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 G4XH65 (/IPI) G4XH65 (/IPI) O08537 (/IPI) O08537 (/IPI) P03372 (/IPI) P03372 (/IPI) P06211 (/IPI) P19785 (/IPI) P19785 (/IPI) Q62986 (/IPI)
(2 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
7 P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS) Q9TV98 (/ISS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
6 P03372 (/IPI) P03372 (/IPI) P06211 (/IPI) Q62986 (/IPI) Q92731 (/IPI) Q92731 (/IPI)
Estrogen response element binding GO:0034056
Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.
6 P03372 (/IDA) P03372 (/IDA) P16058 (/IDA) Q62986 (/IDA) Q92731 (/IDA) Q92731 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
5 P03372 (/IDA) P03372 (/IDA) Q62986 (/IDA) Q92731 (/IDA) Q92731 (/IDA)
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
5 P16058 (/IMP) Q62986 (/IMP) Q92731 (/IMP) Q92731 (/IMP) Q9YHZ7 (/IMP)
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
5 P03372 (/TAS) P03372 (/TAS) P06211 (/TAS) Q92731 (/TAS) Q92731 (/TAS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P03372 (/ISA) P03372 (/ISA) Q92731 (/ISA) Q92731 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P03372 (/ISM) P03372 (/ISM) Q92731 (/ISM) Q92731 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P03372 (/NAS) P03372 (/NAS) Q92731 (/NAS) Q92731 (/NAS)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 P03372 (/IDA) P03372 (/IDA) P19785 (/IDA) P19785 (/IDA)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
4 P03372 (/IPI) P03372 (/IPI) P19785 (/IPI) P19785 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Estrogen response element binding GO:0034056
Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
4 P06211 (/IDA) Q62986 (/IDA) Q9IAK1 (/IDA) Q9YHZ7 (/IDA)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 P03372 (/IPI) P03372 (/IPI) Q92731 (/IPI) Q92731 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Estradiol binding GO:1903924
Interacting selectively and non-covalently with estradiol.
4 P50242 (/ISS) Q0H3B5 (/ISS) Q4ZHP9 (/ISS) Q5YFR8 (/ISS)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Transcription coactivator binding GO:0001223
Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
3 P03372 (/IPI) P03372 (/IPI) P06211 (/IPI)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 P03372 (/IDA) P03372 (/IDA) Q62986 (/IDA)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
3 P03372 (/IPI) P03372 (/IPI) P16058 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 P19785 (/IDA) P19785 (/IDA) Q62986 (/IDA)
TFIIB-class transcription factor binding GO:0001093
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
2 P03372 (/IPI) P03372 (/IPI)
TFIIB-class transcription factor binding GO:0001093
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
2 P19785 (/ISO) P19785 (/ISO)
Transcription coactivator binding GO:0001223
Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
2 P19785 (/ISO) P19785 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 O08537 (/IDA) O08537 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P06211 (/IMP) P16058 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P19785 (/ISO) P19785 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q92731 (/TAS) Q92731 (/TAS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P19785 (/ISO) P19785 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P03372 (/NAS) P03372 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q92731 (/TAS) Q92731 (/TAS)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
2 P06211 (/IDA) Q62986 (/IDA)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
2 Q92731 (/TAS) Q92731 (/TAS)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
2 Q92731 (/TAS) Q92731 (/TAS)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
2 P03372 (/IGI) P03372 (/IGI)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
2 Q92731 (/NAS) Q92731 (/NAS)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
2 P06211 (/IDA) Q62986 (/IDA)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
2 Q92731 (/TAS) Q92731 (/TAS)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
2 P03372 (/IPI) P03372 (/IPI)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
2 P19785 (/ISO) P19785 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 P19785 (/ISO) P19785 (/ISO)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
2 O08537 (/ISO) O08537 (/ISO)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
2 P03372 (/IPI) P03372 (/IPI)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
2 P19785 (/ISO) P19785 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
2 Q9IAK1 (/IDA) W5UDK8 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P03372 (/IPI) P03372 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P19785 (/ISO) P19785 (/ISO)
Nitric-oxide synthase regulator activity GO:0030235
Modulates the activity of nitric oxide synthase.
2 P03372 (/NAS) P03372 (/NAS)
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
2 P03372 (/NAS) P03372 (/NAS)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
2 P19785 (/ISO) P19785 (/ISO)
Type 1 metabotropic glutamate receptor binding GO:0031798
Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor.
2 P19785 (/ISO) P19785 (/ISO)
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
2 P19785 (/ISO) P19785 (/ISO)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
2 P06211 (/IMP) Q62986 (/IMP)
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
2 O08537 (/ISO) O08537 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 O08537 (/ISO) O08537 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P19785 (/ISO) P19785 (/ISO)
Receptor antagonist activity GO:0048019
The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.
2 Q92731 (/NAS) Q92731 (/NAS)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
2 P03372 (/IDA) P03372 (/IDA)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
2 P19785 (/ISO) P19785 (/ISO)
Hsp90 protein binding GO:0051879
Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
2 E5L8C9 (/IPI) P06212 (/IPI)
Estradiol binding GO:1903924
Interacting selectively and non-covalently with estradiol.
2 A0A060X747 (/IDA) P16058 (/IDA)
Estradiol binding GO:1903924
Interacting selectively and non-covalently with estradiol.
2 O08537 (/ISO) O08537 (/ISO)
Steroid hormone binding GO:1990239
Interacting selectively and non-covalently with a steroid hormone.
2 O08537 (/ISO) O08537 (/ISO)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
2 P06211 (/IDA) Q62986 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9IAK1 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P06211 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q6Q6F3 (/IDA)
Androgen binding GO:0005497
Interacting selectively and non-covalently with any androgen, male sex hormones.
1 P16058 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 Q62986 (/IPI)
Type 1 metabotropic glutamate receptor binding GO:0031798
Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor.
1 P06211 (/IPI)
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
1 P06211 (/IPI)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
1 Q62986 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P16058 (/IPI)
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
1 Q62986 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P06211 (/IDA)
Estradiol binding GO:1903924
Interacting selectively and non-covalently with estradiol.
1 Q62986 (/IPI)
Steroid hormone binding GO:1990239
Interacting selectively and non-covalently with a steroid hormone.
1 Q62986 (/IPI)

There are 194 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
30 A0A068EUA1 (/ISS) A0A087R654 (/ISS) A0A087R654 (/ISS) A0A091EZL1 (/ISS) A0A091G8M1 (/ISS) A0A091I716 (/ISS) A0A091MIX0 (/ISS) A0A091P4V0 (/ISS) A0A091V5E3 (/ISS) A0A091W4K7 (/ISS)
(20 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
17 O08537 (/ISS) O08537 (/ISS) P06211 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q95171 (/ISS)
(7 more)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
16 O08537 (/ISS) O08537 (/ISS) P06211 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q62986 (/ISS)
(6 more)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
12 B8JJL3 (/IDA) B8JJL4 (/IDA) P03372 (/IDA) P03372 (/IDA) P57717 (/IDA) Q5PR29 (/IDA) Q7ZU32 (/IDA) Q8AV62 (/IDA) Q90WS8 (/IDA) Q90WS9 (/IDA)
(2 more)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
11 P03372 (/ISS) P03372 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS)
(1 more)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
11 P03372 (/ISS) P03372 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS)
(1 more)
Positive regulation of phospholipase C activity GO:0010863
Any process that increases the rate of phospholipase C activity.
11 P03372 (/ISS) P03372 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS)
(1 more)
Intracellular steroid hormone receptor signaling pathway GO:0030518
A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.
11 P03372 (/ISS) P03372 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS)
(1 more)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
11 P03372 (/ISS) P03372 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS)
(1 more)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
10 P06211 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS) Q9TV98 (/ISS)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
10 P06211 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS) Q9TV98 (/ISS)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
10 P06211 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS) Q9TV98 (/ISS)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
10 P06211 (/ISS) P19785 (/ISS) P19785 (/ISS) P49884 (/ISS) Q29040 (/ISS) Q29040 (/ISS) Q53AD2 (/ISS) Q9QZJ5 (/ISS) Q9QZJ5 (/ISS) Q9TV98 (/ISS)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
6 A0A060X747 (/IDA) P03372 (/IDA) P03372 (/IDA) P16058 (/IDA) P57717 (/IDA) P57782 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 P03372 (/IDA) P03372 (/IDA) Q62986 (/IDA) Q92731 (/IDA) Q92731 (/IDA)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
5 P03372 (/IDA) P03372 (/IDA) P06211 (/IDA) P19785 (/IDA) P19785 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
4 P03372 (/TAS) P03372 (/TAS) Q92731 (/TAS) Q92731 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
4 P03372 (/TAS) P03372 (/TAS) Q92731 (/TAS) Q92731 (/TAS)
Intracellular steroid hormone receptor signaling pathway GO:0030518
A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
4 O08537 (/IMP) O08537 (/IMP) P16058 (/IMP) Q9YHZ7 (/IMP)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
4 P50242 (/ISS) Q0H3B5 (/ISS) Q4ZHP9 (/ISS) Q5YFR8 (/ISS)
Regulation of neuron apoptotic process GO:0043523
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Positive regulation of epidermal growth factor receptor signaling pathway GO:0045742
Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
4 P03372 (/IDA) P03372 (/IDA) Q92731 (/IDA) Q92731 (/IDA)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Sertoli cell proliferation GO:0060011
The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Uterus development GO:0060065
The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.
4 O08537 (/IGI) O08537 (/IGI) P19785 (/IGI) P19785 (/IGI)
Vagina development GO:0060068
The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.
4 O08537 (/IGI) O08537 (/IGI) P19785 (/IGI) P19785 (/IGI)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 Q62986 (/IDA) Q92731 (/IDA) Q92731 (/IDA)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
3 P19785 (/IMP) P19785 (/IMP) Q8AYH0 (/IMP)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
3 P03372 (/IDA) P03372 (/IDA) P16058 (/IDA)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
3 Q62986 (/TAS) Q92731 (/TAS) Q92731 (/TAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P03372 (/IDA) P03372 (/IDA) Q62986 (/IDA)
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
3 H0ZLY1 (/IMP) H0ZRT6 (/IMP) Q91250 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P03372 (/IMP) P03372 (/IMP)
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
2 O08537 (/IMP) O08537 (/IMP)
Antral ovarian follicle growth GO:0001547
Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.
2 P19785 (/IMP) P19785 (/IMP)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
2 O08537 (/ISO) O08537 (/ISO)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 O08537 (/IMP) O08537 (/IMP)
Epithelial cell development GO:0002064
The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
2 P19785 (/IMP) P19785 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 P03372 (/NAS) P03372 (/NAS)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
2 P03372 (/TAS) P03372 (/TAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P19785 (/IDA) P19785 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P03372 (/NAS) P03372 (/NAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q92731 (/TAS) Q92731 (/TAS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P03372 (/TAS) P03372 (/TAS)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
2 P03372 (/IDA) P03372 (/IDA)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
2 P19785 (/ISO) P19785 (/ISO)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
2 P19785 (/ISO) P19785 (/ISO)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 P19785 (/ISO) P19785 (/ISO)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2 Q92731 (/TAS) Q92731 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 O08537 (/IMP) O08537 (/IMP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
2 O08537 (/ISO) O08537 (/ISO)
Androgen metabolic process GO:0008209
The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
2 P19785 (/IMP) P19785 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 O08537 (/IGI) O08537 (/IGI)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
2 P06211 (/IEP) Q62986 (/IEP)
Hormone-mediated apoptotic signaling pathway GO:0008628
A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered.
2 O08537 (/IMP) O08537 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 E5L8C9 (/IDA) P06212 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P03372 (/IDA) P03372 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P19785 (/ISO) P19785 (/ISO)
Positive regulation of phospholipase C activity GO:0010863
Any process that increases the rate of phospholipase C activity.
2 P19785 (/ISO) P19785 (/ISO)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 P03372 (/TAS) P03372 (/TAS)
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
2 P03372 (/TAS) P03372 (/TAS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 Q92731 (/NAS) Q92731 (/NAS)
Intracellular steroid hormone receptor signaling pathway GO:0030518
A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.
2 P06211 (/IDA) Q62986 (/IDA)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
2 P03372 (/NAS) P03372 (/NAS)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
2 P06211 (/IEP) Q62986 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
2 P19785 (/ISO) P19785 (/ISO)
Regulation of intracellular estrogen receptor signaling pathway GO:0033146
Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
2 P03372 (/TAS) P03372 (/TAS)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
2 O08537 (/ISO) O08537 (/ISO)
Regulation of toll-like receptor signaling pathway GO:0034121
Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
2 P19785 (/IMP) P19785 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 O08537 (/IMP) O08537 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
2 P19785 (/IMP) P19785 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 O08537 (/ISO) O08537 (/ISO)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
2 P03372 (/IDA) P03372 (/IDA)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
2 P19785 (/ISO) P19785 (/ISO)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P03372 (/IDA) P03372 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P19785 (/ISO) P19785 (/ISO)
Regulation of neuron apoptotic process GO:0043523
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
2 P06211 (/IDA) Q62986 (/IDA)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
2 P19785 (/ISO) P19785 (/ISO)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
2 O08537 (/ISO) O08537 (/ISO)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
2 P19785 (/ISO) P19785 (/ISO)
Positive regulation of epidermal growth factor receptor signaling pathway GO:0045742
Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2 P06211 (/IMP) Q62986 (/IMP)
Negative regulation of mitotic nuclear division GO:0045839
Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
2 P19785 (/NAS) P19785 (/NAS)
Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899
Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
2 P03372 (/IDA) P03372 (/IDA)
Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899
Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
2 P19785 (/ISO) P19785 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P19785 (/IMP) P19785 (/IMP)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
2 P19785 (/ISO) P19785 (/ISO)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 P19785 (/IMP) P19785 (/IMP)
Negative regulation of behavior GO:0048521
Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
2 O08537 (/ISO) O08537 (/ISO)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
2 P06211 (/IMP) Q62986 (/IMP)
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
2 P19785 (/IDA) P19785 (/IDA)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
2 P19785 (/ISO) P19785 (/ISO)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
2 O08537 (/IMP) O08537 (/IMP)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
2 O08537 (/ISO) O08537 (/ISO)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 P19785 (/IMP) P19785 (/IMP)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
2 P19785 (/ISO) P19785 (/ISO)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 P03372 (/TAS) P03372 (/TAS)
Sertoli cell development GO:0060009
The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate.
2 P06211 (/IEP) Q62986 (/IEP)
Sertoli cell proliferation GO:0060011
The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
2 P06211 (/IMP) Q62986 (/IMP)
Prostate epithelial cord elongation GO:0060523
The developmental growth process in which solid chords of prostate epithelium increase in length.
2 P19785 (/IMP) P19785 (/IMP)
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527
The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.
2 P19785 (/IMP) P19785 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2 O08537 (/ISO) O08537 (/ISO)
Regulation of branching involved in prostate gland morphogenesis GO:0060687
Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.
2 P19785 (/IMP) P19785 (/IMP)
Prostate gland epithelium morphogenesis GO:0060740
The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
2 O08537 (/IMP) O08537 (/IMP)
Epithelial cell maturation involved in prostate gland development GO:0060743
The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
2 O08537 (/IMP) O08537 (/IMP)
Mammary gland branching involved in pregnancy GO:0060745
The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy.
2 P19785 (/IMP) P19785 (/IMP)
Mammary gland alveolus development GO:0060749
The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.
2 P19785 (/IMP) P19785 (/IMP)
Epithelial cell proliferation involved in mammary gland duct elongation GO:0060750
The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth.
2 P19785 (/IMP) P19785 (/IMP)
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
2 O08537 (/IMP) O08537 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P06211 (/IDA) Q62986 (/IDA)
Protein localization to chromatin GO:0071168
Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
2 P03372 (/IMP) P03372 (/IMP)
Protein localization to chromatin GO:0071168
Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
2 P19785 (/ISO) P19785 (/ISO)
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
2 P19785 (/IMP) P19785 (/IMP)
Negative regulation of triglyceride metabolic process GO:0090209
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.
2 P19785 (/ISO) P19785 (/ISO)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
2 O08537 (/ISO) O08537 (/ISO)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
2 P06211 (/IDA) Q62986 (/IDA)
Negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799
Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
2 P03372 (/IMP) P03372 (/IMP)
Negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799
Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
2 P19785 (/ISO) P19785 (/ISO)
Negative regulation of feeding behavior GO:2000252
Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.
2 O08537 (/ISO) O08537 (/ISO)
Negative regulation of reactive oxygen species metabolic process GO:2000378
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
2 O08537 (/ISO) O08537 (/ISO)
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
1 Q62986 (/IEP)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
1 Q62986 (/IDA)
Osteoblast development GO:0002076
The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
1 P06211 (/IEP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q6Q6F3 (/IDA)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 P06211 (/IDA)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P06211 (/IDA)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 Q62986 (/IMP)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
1 Q9IAK1 (/TAS)
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
1 Q62986 (/IEP)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 P57717 (/IDA)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 Q9IAK1 (/TAS)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
1 Q62986 (/IEP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 Q62986 (/IEP)
Positive regulation of phospholipase C activity GO:0010863
Any process that increases the rate of phospholipase C activity.
1 P06211 (/IDA)
Positive regulation of receptor biosynthetic process GO:0010870
Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P16058 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q62986 (/IEP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 Q62986 (/IEP)
Response to insecticide GO:0017085
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
1 Q62986 (/IEP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 Q62986 (/IEP)
Amygdala development GO:0021764
The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.
1 Q62986 (/IEP)
Hypothalamus development GO:0021854
The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
1 Q62986 (/IEP)
Prostate gland development GO:0030850
The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
1 Q62986 (/IEP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 Q62986 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P16058 (/IMP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 P16058 (/IDA)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 Q62986 (/IEP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 Q62986 (/IMP)
Response to genistein GO:0033595
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.
1 Q62986 (/IEP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q62986 (/IEP)
Oviduct morphogenesis GO:0035848
The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.
1 Q8AYH0 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q62986 (/IEP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q62986 (/IDA)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 Q62986 (/IEP)
Response to human chorionic gonadotropin GO:0044752
Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.
1 Q62986 (/IEP)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
1 Q62986 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 Q62986 (/IEP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P06211 (/TAS)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
1 P06211 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 P16058 (/IMP)
Decidualization GO:0046697
The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
1 P06211 (/IEP)
Negative regulation of behavior GO:0048521
Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
1 Q62986 (/IDA)
Posterior lateral line neuromast primordium migration GO:0048920
The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.
1 P57717 (/IGI)
Posterior lateral line neuromast primordium migration GO:0048920
The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.
1 P57717 (/IMP)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
1 P06211 (/IMP)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 Q62986 (/IDA)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 Q9YHZ7 (/IMP)
Male mating behavior GO:0060179
The specific behavior of a male organism that is associated with reproduction.
1 Q8AYH0 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 Q62986 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q62986 (/IMP)
Cellular response to magnetism GO:0071259
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus.
1 Q62986 (/IEP)
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 P57717 (/IDA)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q62986 (/IEP)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q9YHZ7 (/IMP)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q62986 (/IEP)
Response to dexamethasone GO:0071548
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 Q62986 (/IEP)
Negative regulation of triglyceride metabolic process GO:0090209
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.
1 P06211 (/IDA)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
1 Q62986 (/IMP)
Response to salt GO:1902074
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.
1 Q62986 (/IEP)
Response to bisphenol A GO:1903925
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus.
1 Q62986 (/IEP)
Cloacal gland development GO:1904484
The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure.
1 Q8AYH0 (/IMP)
Response to 17alpha-ethynylestradiol GO:1904486
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus.
1 Q8AYH0 (/IDA)
Baculum development GO:1990375
The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure.
1 P06211 (/IEP)
Negative regulation of feeding behavior GO:2000252
Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.
1 Q62986 (/IMP)
Negative regulation of reactive oxygen species metabolic process GO:2000378
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
1 Q62986 (/IMP)
Positive regulation of testosterone secretion GO:2000845
Any process that activates or increases the frequency, rate or extent of testosterone secretion.
1 Q8AYH0 (/IMP)

There are 42 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
59 A0A068EUA1 (/ISS) A0A087R654 (/ISS) A0A087R654 (/ISS) A0A091EZL1 (/ISS) A0A091G8M1 (/ISS) A0A091I716 (/ISS) A0A091MIX0 (/ISS) A0A091P4V0 (/ISS) A0A091V5E3 (/ISS) A0A091W4K7 (/ISS)
(49 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
17 A0A060X747 (/IDA) E5L8C9 (/IDA) F1MX59 (/IDA) O08537 (/IDA) O08537 (/IDA) P03372 (/IDA) P03372 (/IDA) P06211 (/IDA) P06212 (/IDA) P16058 (/IDA)
(7 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 E5L8C9 (/IDA) O08537 (/IDA) O08537 (/IDA) P03372 (/IDA) P03372 (/IDA) P06211 (/IDA) P06212 (/IDA) P19785 (/IDA) P19785 (/IDA) Q62986 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
4 P50242 (/ISS) Q0H3B5 (/ISS) Q4ZHP9 (/ISS) Q5YFR8 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P03372 (/TAS) P03372 (/TAS) Q92731 (/TAS) Q92731 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P06211 (/IDA) Q62986 (/IDA) Q92731 (/IDA) Q92731 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P03372 (/IDA) P03372 (/IDA) P06211 (/IDA) Q62986 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 O08537 (/ISO) O08537 (/ISO) P19785 (/ISO) P19785 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
2 P03372 (/IDA) P03372 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
2 P19785 (/ISO) P19785 (/ISO)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 A0A060X747 (/IDA) P16058 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P16058 (/IC) Q6Q6F3 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q92731 (/TAS) Q92731 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P03372 (/TAS) P03372 (/TAS)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
2 O08537 (/ISO) O08537 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9IAK1 (/IDA) W5UDK8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P03372 (/NAS) P03372 (/NAS)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
2 P19785 (/ISO) P19785 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P03372 (/IMP) P03372 (/IMP)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P19785 (/ISO) P19785 (/ISO)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
2 O08537 (/ISO) O08537 (/ISO)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
2 P03372 (/IDA) P03372 (/IDA)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
2 P19785 (/ISO) P19785 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 P06211 (/IDA) Q62986 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O08537 (/ISO) O08537 (/ISO)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
2 P19785 (/ISO) P19785 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
2 P06211 (/IDA) Q62986 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 P06211 (/IDA) Q62986 (/IDA)
Transcriptional preinitiation complex GO:0097550
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.
2 P03372 (/IDA) P03372 (/IDA)
Transcriptional preinitiation complex GO:0097550
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.
2 P19785 (/ISO) P19785 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 Q62986 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P06211 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P06211 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 Q62986 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q62986 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 P06211 (/IDA)