The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Death Domain, Fas
".
FunFam 90: Caspase recruitment domain family member 8
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q9Y2G2 (/IPI) Q9Y2G2 (/IPI) |
|
Cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656
Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
NACHT domain binding GO:0032089
Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.
|
2 | Q9Y2G2 (/IPI) Q9Y2G2 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
CARD domain binding GO:0050700
Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
|
2 | Q9Y2G2 (/IPI) Q9Y2G2 (/IPI) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
|
2 | Q9Y2G2 (/IMP) Q9Y2G2 (/IMP) |
|
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
2 | Q9Y2G2 (/IMP) Q9Y2G2 (/IMP) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Negative regulation of interleukin-1 beta secretion GO:0050713
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Inhibition of cysteine-type endopeptidase activity GO:0097340
Any process that prevents the activation of an inactive cysteine-type endopeptidase.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9Y2G2 (/TAS) Q9Y2G2 (/TAS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
NLRP3 inflammasome complex GO:0072559
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
|
2 | Q9Y2G2 (/IDA) Q9Y2G2 (/IDA) |
|
NLRP3 inflammasome complex GO:0072559
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
|
1 | Q5RAV7 (/ISS) |
