CATH Superfamily 1.10.533.10

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
1	Unc-5 netrin receptor B	931	3D	1wmgF00	-	94.4
2	Ankyrin-3 isoform 2	670	3D	4o6xB00	-	94.2
3	Caspase recruitment domain family, member 11	495	3D	4i16A00	-	95.3
4	Death effector domain-containing protein-like	183		-	-	76.3
5	Tumor necrosis factor receptor superfamily member 21	174	3D	2dbhA01	-	39.0
6	Tumor necrosis factor receptor superfamily member EDAR	168		-	-	40.6
7	death domain-containing protein CRADD isoform X1	162	3D	3crdA00	-	77.0
13	Apoptosis-associated speck-like protein containing a CARD	160	3D	6n1hP00	-	95.9
8	Death associated protein kinase 1	159		-	-	60.0
9	tumor necrosis factor receptor superfamily member 21	154		-	-	75.0
10	Ankyrin 1	150	3D	2yviA00	-	70.1
14	Apoptotic protease-activating factor 1	149	3D	5wvcE00	-	69.8
11	Myeloid cell nuclear differentiation antigen	138	3D	2dbgA00	-	96.2
12	baculoviral IAP repeat-containing protein 2	135	3D	3t6pA03	-	78.4
15	Caspase recruitment domain-containing protein 19	132	3D	4fh0B00	-	83.3
16	CASP8 and FADD-like apoptosis regulator	128		-	-	94.7
17	caspase-8 isoform X1	126	3D	4zbwB01	-	72.3
18	Nuclear factor NF-kappa-B p105 subunit isoform 1	118	3D	2dbfA01	-	52.5
19	NACHT, LRR and PYD domains-containing protein 3	116	3D	3qf2B00	-	52.3
20	CASP8 and FADD like apoptosis regulator	108		-	-	77.5
21	caspase-8 isoform X1	104	3D	4zbwB02	-	79.9
29	Myeloid differentiation primary response protein MyD88	101	3D	3mopF00	-	97.2
28	Interleukin 1 receptor-associated kinase 4	101	3D	3mopJ00	-	84.7
22	B-cell lymphoma/leukemia 10	99	3D	2mb9A00	-	81.9
25	THO complex subunit 1	98	3D	1wxpA01	-	71.7
53	Apoptosis-associated speck-like protein containing a CARD	98	3D	2n1fO00	-	80.6
23	DNA-binding death effector domain-containing protein 2	98		-	-	70.4
24	caspase-2 isoform X1	98		-	-	91.7
26	astrocytic phosphoprotein PEA-15 isoform X1	96	3D	1n3kA00	-	15.1
30	Interleukin-1 receptor-associated kinase-like 2	96	3D	3mopN00	-	93.2
34	tumor necrosis factor receptor superfamily member 16	95	3D	2n97B00	-	75.0
27	Interleukin-1 receptor-associated kinase 1 Predicted	95		-	-	72.7
33	p53-induced death domain-containing protein 1 isoform X1	93	3D	2of5L00	-	72.3
31	Caspase 1, isoform CRA_b	93	3D	1dgnA00	-	97.9
63	Mitochondrial antiviral-signaling protein	90	3D	2vgqA03	-	94.8
32	Nucleotide-binding oligomerization domain-containing protein 2	89		-	-	66.3
35	nucleolar protein 3 isoform X5	87	3D	4uz0B00	-	40.5
41	Caspase 9	86	3D	5wvcF00	-	89.2
37	Receptor-interacting serine/threonine-protein kinase 2	85	3D	2n7zA00	-	86.9
36	Ankyrin 2, isoform M	84		-	-	14.4
39	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	83	3D	2g7rB00	-	76.0
38	Caspase 10	82		-	-	94.9
47	Nucleotide-binding oligomerization domain-containing protein 1	81	3D	4jqwA00	-	77.6
40	tumor necrosis factor receptor superfamily member 25	80		-	-	36.0
42	Tumor necrosis factor receptor type 1-associated DEATH domain protein	79		-	-	48.0
43	Tumor necrosis factor receptor superfamily member 10A	78		-	-	94.7
44	Tumor necrosis factor receptor superfamily member 1A	75	3D	1ichA00	-	85.6
45	Nucleotide-binding oligomerization domain-containing protein 2	72		-	-	73.0
56	NACHT, LRR and PYD domains-containing protein 14	71	3D	4ewiB00	-	79.9
46	Si:ch211-196f19.1	70		-	-	81.6
48	MEFV, pyrin innate immunity regulator	69	3D	2mpcA00	-	65.9
59	Fas-associated via death domain	69	3D	1fadA00	-	97.0
49	NLR family pyrin domain containing 1	67	3D	1pn5A00	-	68.9
57	Tumor necrosis factor receptor superfamily member 6	67	3D	3ezqO00	-	76.7
50	E3 ubiquitin-protein ligase XIAP	66		-	-	71.8
58	death domain-containing protein CRADD isoform X1	64	3D	2of5G00	-	79.5
51	Baculoviral IAP repeat containing 2	64		-	-	57.7
52	Putative receptor-interacting serine/threonine-protein kinase 1	63		-	-	73.0
55	Interleukin-1 receptor-associated kinase 3	60		-	-	71.6
54	Unc-5 family C-terminal like	60		-	-	42.4
69	NACHT, LRR and PYD domains-containing protein 6	58	3D	6ncvV00	-	85.8
72	Probable ATP-dependent RNA helicase DDX58	57	3D	4p4hH02	-	82.6
60	disks large homolog 5 isoform X2	55		-	-	13.1
62	Fas-associated via death domain	55	3D	2gf5A01	-	86.6
61	nuclear factor NF-kappa-B p100 subunit isoform X1	55	3D	2d96A01	-	62.0
78	Probable ATP-dependent RNA helicase DDX58	51	3D	4p4hH01	-	87.1
64	NLR family pyrin domain containing 12	49	3D	2l6aA00	-	67.8
65	Ectodysplasin-A receptor-associated adapter protein	43		-	-	81.0
66	Tumor necrosis factor receptor superfamily member 11B	43		-	-	44.4
67	NLR family pyrin domain containing 2	42		-	-	79.0
68	NLR family CARD domain containing 4	37		-	-	76.9
70	Caspase 10	36		-	-	61.2
76	Interferon-inducible protein AIM2	32	3D	4o7qA00	-	94.7
71	NACHT, LRR and PYD domains-containing protein 5	32		-	-	42.9
74	NLR family pyrin domain containing 7	32	3D	2km6A00	-	34.1
73	Inactive caspase-12	32		-	-	98.4
75	Baculoviral IAP repeat containing 7	30		-	-	70.7
77	Interferon-induced helicase C domain-containing protein 1	28		-	-	42.7
79	IGF like family receptor 1	28		-	-	74.3
80	Uncharacterized protein	26		-	-	99.5
81	Apoptotic protease-activating factor 1	25		-	-	98.2
82	Uncharacterized protein	24		-	-	58.5
84	Interferon-induced with helicase C domain 1	21		-	-	73.9
83	Leucine rich repeats and death domain containing 1	21		-	-	44.2
85	Baculoviral IAP repeat containing 7	20		-	-	47.8
87	Uncharacterized protein	19		-	-	81.6
86	AO66 ankyrin	19		-	-	14.6
88	P53-induced death domain protein 1	18		-	-	99.2
89	E3 ubiquitin-protein ligase TTC3	17		-	-	10.8
90	Caspase recruitment domain family member 8	17		-	-	70.5
91	NLR family pyrin domain containing 10	16	3D	2m5vA00	-	45.2
92	Netrin receptor unc-5	15		-	-	67.0
94	Interleukin-1 receptor-associated kinase	15		-	-	95.8
93	Death-associated protein kinase dapk-1	15		-	-	1.3
95	Predicted protein	13		-	-	90.6
96	Neurotrophin receptor associated death domain	12		-	-	69.9
99	Uncharacterized protein	11		-	-	96.1
98	Hematopoietic death receptor	11		-	-	67.5
100	NLR family pyrin domain containing 11	11		-	-	0.0
101	Receptor-interacting serine/threonine kinase 1	11		-	-	73.4
97	Death effector domain-containing 1	11		-	-	35.7
103	MALT1 paracaspase	10		-	-	24.4
102	Imd	10		-	-	21.3
104	Si:dkey-103e21.5	10		-	-	80.8
105	Fas-associated death domain protein	9		-	-	37.5
107	Nucleotide-binding oligomerization domain-containing protein 1	9		-	-	42.5
106	Unc-5, isoform B	9		-	-	9.9
112	Uncharacterized protein	8		-	-	23.9
110	astrocytic phosphoprotein PEA-15 isoform X2	8		-	-	0.0
109	GG10810	8		-	-	79.2
115	Uncharacterized protein	8		-	-	75.5
111	astrocytic phosphoprotein PEA-15 isoform X2	8		-	-	0.0
113	Baculoviral IAP repeat-containing 3	8		-	-	47.9
108	THO complex 1	8		-	-	38.7
151	Viral CASP8 and FADD-like apoptosis regulator	8	3D	2bbzD01	-	0.0
114	Caspase Dronc	8		-	-	93.2
149	Viral CASP8 and FADD-like apoptosis regulator	7	3D	2bbzD02	-	0.0
156	Cell death protein 4	7	3D	4m9xA01	-	19.8
119	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	6		-	-	18.4
117	Uncharacterized protein	6		-	-	42.1
130	Protein Tube	6	3D	1d2zD00	-	11.4
140	Death domain-containing membrane protein NRADD	6	3D	6hj7A00	-	67.7
118	TUBE	6		-	-	77.3
116	Caspase-15	6		-	-	72.3
129	Predicted protein	5		-	-	84.9
124	Uncharacterized protein	5		-	-	82.1
126	Tumor necrosis factor receptor superfamily, member 1a	5		-	-	13.8
121	Uncharacterized protein	5		-	-	10.8
123	Nerve growth factor receptor b	5		-	-	31.1
128	Uncharacterized protein	5		-	-	74.3
139	Ankyrin-2	5	3D	4d8oA04	-	14.3
125	Uncharacterized protein	5		-	-	72.5
127	Uncharacterized protein	5		-	-	72.2
120	B-cell lymphoma/leukemia 10-like	5		-	-	13.9
122	Caspase 8a	5		-	-	2.8
131	Fas-associated death domain protein	4		-	-	42.8
141	Uncharacterized protein	4		-	-	34.7
143	Caspase 8, apoptosis-related cysteine peptidase,-like 2	4		-	-	1.4
133	Caspase b	4		-	-	21.9
137	Uncharacterized protein	4		-	-	19.1
135	SBP S-ribonuclease binding protein	4		-	-	71.4
142	Uncharacterized protein	4		-	-	53.0
132	Cell death protein 3	4		-	-	23.7
144	Apoptosis-associated speck-like protein-containing a CARD	4		-	-	27.6
134	Netrin receptor unc-5	4		-	-	4.9
136	Interferon-induced with helicase C domain 1	4		-	-	0.0
138	Interleukin-1 receptor-associated kinase 4	4		-	-	11.3
170	Uncharacterized protein	3		-	-	13.7
165	Ankyrin	3		-	-	1.3
168	NOD2b protein	3		-	-	0.0
148	CASP2 and RIPK1 domain containing adaptor with death domain	3		-	-	5.2
157	NALP2	3		-	-	21.4
163	Putative BOI-related E3 ubiquitin-protein ligase 3	3		-	-	8.9
176	Baculoviral IAP repeat-containing protein 7	3		-	-	74.1
175	Apoptotic protease-activating factor, putative	3		-	-	79.0
154	Uncharacterized protein	3		-	-	12.7
147	Uncharacterized protein	3		-	-	7.6
145	Uncharacterized protein	3		-	-	67.4
152	Caspase-8	3		-	-	27.6
160	Uncharacterized protein	3		-	-	0.0
167	Nerve growth factor receptor	3		-	-	5.4
150	CASP2 and RIPK1 domain containing adaptor with death domain	3		-	-	2.6
159	Predicted protein	3		-	-	69.8
162	Myeloid differentiation primary response protein MyD88	3		-	-	1.1
169	Guanylate-binding protein 4	3		-	-	4.2
172	X-linked inhibitor of apoptosis	3		-	-	6.6
158	Baculoviral IAP repeat-containing protein 7	3		-	-	22.6
171	Uncharacterized protein	3		-	-	10.9
166	Melanoma differentiation associated gene 5	3		-	-	9.4
153	Caspase-8	3		-	-	2.2
155	Zgc:194469	3		-	-	0.0
161	Uncharacterized protein	3		-	-	13.0
174	Caspase 9	3		-	-	45.8
146	Caspase recruitment domain family, member 6	3		-	-	10.5
164	Cyclin T-dependent kinase CDK9, putative	3		-	-	5.6
173	Predicted protein	3		-	-	81.2
232	interleukin-1 receptor-associated kinase 4	2		-	-	0.0
207	Predicted protein	2		-	-	39.9
184	Uncharacterized protein	2		-	-	0.0
181	Putative nuclear matrix protein	2		-	-	10.2
224	Importin subunit alpha-7	2		-	-	1.3
192	Uncharacterized protein	2		-	-	1.2
199	Uncharacterized protein	2		-	-	0.0
179	Uncharacterized protein	2		-	-	2.4
234	Uncharacterized protein	2		-	-	5.9
193	Predicted protein	2		-	-	2.7
205	Uncharacterized protein	2		-	-	10.1
186	Uncharacterized protein	2		-	-	0.0
226	Uncharacterized protein	2		-	-	7.5
237	Uncharacterized protein	2		-	-	43.3
215	Uncharacterized protein	2		-	-	0.0
180	Si:dkeyp-97b10.3	2		-	-	0.0
187	Uncharacterized protein	2		-	-	2.5
212	Predicted protein	2		-	-	5.0
202	Uncharacterized protein	2		-	-	0.0
200	Uncharacterized protein	2		-	-	0.0
228	Predicted protein	2		-	-	0.0
211	Uncharacterized protein	2		-	-	0.0
218	Ankyrin-3	2		-	-	0.0
189	Predicted protein	2		-	-	0.0
221	E3 ubiquitin-protein ligase HERC2	2		-	-	0.0
182	Si:dkeyp-97b10.3	2		-	-	2.5
230	Putative BOI-related E3 ubiquitin-protein ligase 3	2		-	-	0.0
206	Death-associated inhibitor of apoptosis 2	2		-	-	41.1
197	V-FLIP	2		-	-	2.9
190	Predicted protein	2		-	-	1.3
223	Uncharacterized protein	2		-	-	6.5
216	Tumor necrosis factor receptor superfamily member 6	2		-	-	0.0
191	V-FLIP	2		-	-	4.1
225	Uncharacterized protein	2		-	-	1.3
222	NLR family, CARD domain-containing 3-like 1	2		-	-	0.0
217	Fas cell surface death receptor	2		-	-	3.8
209	Uncharacterized protein	2		-	-	45.5
178	THO complex subunit 1 isoform X1	2		-	-	0.0
233	Ssl-1	2		-	-	1.1
183	Predicted protein	2		-	-	0.0
204	Uncharacterized protein	2		-	-	21.3
236	Predicted protein	2		-	-	47.4
177	CARD domain-containing protein E10	2		-	-	0.0
227	Si:dkey-61p9.9	2		-	-	0.0
214	Predicted protein	2		-	-	4.1
196	Apoptosis-associated speck-like protein containing a CARD	2		-	-	0.0
194	Protein MC160	2		-	-	9.6
235	Uncharacterized protein	2		-	-	38.2
185	Uncharacterized protein	2		-	-	12.7
198	Uncharacterized protein	2		-	-	0.0
229	Uncharacterized protein	2		-	-	5.4
210	Uncharacterized protein	2		-	-	0.0
213	Tumor necrosis factor receptor superfamily, member 1a	2		-	-	0.0
195	MC160	2		-	-	3.9
188	Uncharacterized protein	2		-	-	1.3
203	CARD15	2		-	-	11.5
219	Predicted protein	2		-	-	1.3
220	Predicted protein	2		-	-	0.0
208	CARD- and ANK-containing Inflammasome Adaptor Protein	2		-	-	45.0
201	Caspase	2		-	-	2.2
231	Predicted protein	2		-	-	4.7
294	Uncharacterized protein	1		-	-	0.0
305	Retinoic acid-inducible protein Ia	1		-	-	0.0
281	Putative inhibitor of apoptosis	1		-	-	0.0
252	Uncharacterized protein	1		-	-	0.0
279	Predicted protein	1		-	-	0.0
263	Uncharacterized protein	1		-	-	0.0
310	Uncharacterized protein	1		-	-	0.0
273	Uncharacterized protein	1		-	-	0.0
258	Caspase-8	1		-	-	0.0
248	Uncharacterized protein	1		-	-	0.0
288	I Kappa B homolog	1		-	-	0.0
264	Uncharacterized protein	1		-	-	0.0
297	Predicted protein	1		-	-	0.0
283	Uncharacterized protein	1		-	-	0.0
300	Uncharacterized protein	1		-	-	0.0
256	Uncharacterized protein	1		-	-	0.0
270	Uncharacterized protein	1		-	-	0.0
261	Uncharacterized protein	1		-	-	0.0
285	Uncharacterized protein	1		-	-	0.0
257	Uncharacterized protein	1		-	-	0.0
307	Interleukin 1 receptor associated kinase 1	1		-	-	0.0
299	NACHT, LRR and PYD domains-containing protein 9B	1		-	-	0.0
247	Uncharacterized protein	1		-	-	0.0
289	Uncharacterized protein	1		-	-	0.0
290	Predicted protein	1		-	-	0.0
242	Uncharacterized protein	1		-	-	0.0
309	Uncharacterized protein	1		-	-	0.0
254	CASP8 and FADD-like apoptosis regulator a	1		-	-	0.0
316	Uncharacterized protein	1		-	-	0.0
314	Uncharacterized protein	1		-	-	0.0
302	Uncharacterized protein	1		-	-	0.0
287	Uncharacterized protein	1		-	-	0.0
274	Si:ch211-112c15.8	1		-	-	0.0
250	Uncharacterized protein	1		-	-	0.0
276	Predicted protein	1		-	-	0.0
240	Uncharacterized protein	1		-	-	0.0
239	Uncharacterized protein	1		-	-	0.0
269	Uncharacterized protein	1		-	-	0.0
312	Uncharacterized protein	1		-	-	0.0
245	Uncharacterized protein	1		-	-	0.0
266	Baculoviral IAP repeat containing 7	1		-	-	0.0
304	Uncharacterized protein	1		-	-	0.0
311	Uncharacterized protein	1		-	-	0.0
272	Uncharacterized protein	1		-	-	0.0
262	Uncharacterized protein	1		-	-	0.0
278	Uncharacterized protein	1		-	-	0.0
293	NLR family CARD domain containing 3	1		-	-	0.0
267	Uncharacterized protein	1		-	-	0.0
280	Uncharacterized protein	1		-	-	0.0
253	Uncharacterized protein	1		-	-	0.0
260	Uncharacterized protein	1		-	-	0.0
259	Uncharacterized protein	1		-	-	0.0
249	Uncharacterized protein	1		-	-	0.0
244	Si:dkey-265e15.2	1		-	-	0.0
295	Uncharacterized protein	1		-	-	0.0
296	Uncharacterized protein	1		-	-	0.0
265	Uncharacterized protein	1		-	-	0.0
282	Uncharacterized protein	1		-	-	0.0
306	Uncharacterized protein	1		-	-	0.0
246	Uncharacterized protein	1		-	-	0.0
308	Retinoic acid-inducible protein Ia	1		-	-	0.0
301	Uncharacterized protein	1		-	-	0.0
315	Uncharacterized protein	1		-	-	0.0
284	NLR family, CARD domain-containing 3-like	1		-	-	0.0
271	Tumor necrosis factor receptor superfamily member 10b	1		-	-	0.0
298	Uncharacterized protein	1		-	-	0.0
243	Uncharacterized protein	1		-	-	0.0
268	Predicted protein	1		-	-	0.0
238	Uncharacterized protein	1		-	-	0.0
255	Uncharacterized protein	1		-	-	0.0
303	Apoptosis 2 inhibitor-like Protein	1		-	-	0.0
313	Baculoviral IAP repeat containing 7	1		-	-	0.0
286	Uncharacterized protein	1		-	-	0.0
275	Uncharacterized protein	1		-	-	0.0
251	Caspase 10	1		-	-	0.0
292	Predicted protein	1		-	-	0.0
291	Uncharacterized protein	1		-	-	0.0
241	Uncharacterized protein	1		-	-	0.0
277	Si:ch211-108d22.2	1		-	-	0.0