The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 48: MEFV, pyrin innate immunity regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 O15553 (/NAS) Q9JJ25 (/NAS) Q9JJ26 (/NAS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 O15553 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9JJ26 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O15553 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O15553 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9JJ26 (/ISO)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Negative regulation of NLRP3 inflammasome complex assembly GO:1900226
Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 O15553 (/IDA)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 Q9JJ26 (/ISO)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 O15553 (/IDA)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q9JJ26 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q9JJ25 (/IEP)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
1 O15553 (/IMP)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
1 Q9JJ26 (/ISO)
Negative regulation of interleukin-12 production GO:0032695
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
1 O15553 (/IMP)
Negative regulation of interleukin-12 production GO:0032695
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
1 Q9JJ26 (/ISO)
Response to silicon dioxide GO:0034021
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus.
1 Q9JJ25 (/IEP)
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
1 O15553 (/IDA)
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
1 Q9JJ26 (/ISO)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 O15553 (/IMP)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 Q9JJ26 (/ISO)
Negative regulation of macrophage inflammatory protein 1 alpha production GO:0071641
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha.
1 O15553 (/IMP)
Negative regulation of macrophage inflammatory protein 1 alpha production GO:0071641
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha.
1 Q9JJ26 (/ISO)
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
1 O15553 (/IMP)
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q9JJ26 (/ISO)
Negative regulation of NLRP3 inflammasome complex assembly GO:1900226
Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly.
1 O15553 (/IMP)
Negative regulation of NLRP3 inflammasome complex assembly GO:1900226
Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly.
1 Q9JJ26 (/ISO)
Positive regulation of cysteine-type endopeptidase activity GO:2001056
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
1 O15553 (/IDA)
Positive regulation of cysteine-type endopeptidase activity GO:2001056
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
1 Q9JJ26 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
2 Q9JJ25 (/ISS) Q9JJ26 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O15553 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9JJ26 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O15553 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9JJ26 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O15553 (/TAS)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
1 O15553 (/IDA)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
1 Q9JJ26 (/ISO)
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