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CATH Superfamily 1.10.533.10

Death Domain, Fas

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 37: Receptor-interacting serine/threonine-protein kina...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 9 A0A0S2Z4Z8 A0A0S2Z4Z8 O43353 O43353 P58801 P58801 Q3SZJ2 Q547H1 Q547H1
Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
 9 A0A0S2Z4Z8 A0A0S2Z4Z8 O43353 O43353 P58801 P58801 Q3SZJ2 Q547H1 Q547H1
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