The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35: nucleolar protein 3 isoform X5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O60936 (/IPI) O60936 (/IPI) Q62881 (/IPI) Q9D1X0 (/IPI) Q9D1X0 (/IPI)
Death effector domain binding GO:0035877
Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).
3 Q62881 (/IPI) Q9D1X0 (/IPI) Q9D1X0 (/IPI)
Caspase binding GO:0089720
Interacting selectively and non-covalently with a caspase family protein.
3 O60936 (/IPI) O60936 (/IPI) Q62881 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 O60936 (/TAS) O60936 (/TAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 Q9D1X0 (/IPI) Q9D1X0 (/IPI)
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
2 Q9D1X0 (/IPI) Q9D1X0 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 O60936 (/IMP) O60936 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Death effector domain binding GO:0035877
Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O60936 (/IPI) O60936 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 O60936 (/IDA) O60936 (/IDA)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Caspase binding GO:0089720
Interacting selectively and non-covalently with a caspase family protein.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 Q62881 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q62881 (/IPI)

There are 69 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
5 O60936 (/IMP) O60936 (/IMP) Q62881 (/IMP) Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298
Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.
4 O60936 (/ISS) O60936 (/ISS) Q9D1X0 (/ISS) Q9D1X0 (/ISS)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
3 Q62881 (/ISS) Q9D1X0 (/ISS) Q9D1X0 (/ISS)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
3 Q62881 (/ISS) Q9D1X0 (/ISS) Q9D1X0 (/ISS)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
3 O60936 (/IDA) O60936 (/IDA) Q62881 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
2 O60936 (/IDA) O60936 (/IDA)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
2 O60936 (/TAS) O60936 (/TAS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Cardiac muscle cell apoptotic process GO:0010659
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Negative regulation of striated muscle cell apoptotic process GO:0010664
Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880
Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of muscle atrophy GO:0014736
Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
2 O60936 (/IDA) O60936 (/IDA)
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Response to injury involved in regulation of muscle adaptation GO:0014876
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 O60936 (/TAS) O60936 (/TAS)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Smooth muscle cell proliferation GO:0048659
The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 O60936 (/IDA) O60936 (/IDA)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of mitochondrial calcium ion concentration GO:0051562
Any process that decreases the concentration of calcium ions in mitochondria.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of necrotic cell death GO:0060547
Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2 Q9D1X0 (/ISS) Q9D1X0 (/ISS)
Intrinsic apoptotic signaling pathway GO:0097193
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Inhibition of cysteine-type endopeptidase activity GO:0097340
Any process that prevents the activation of an inactive cysteine-type endopeptidase.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Regulation of NIK/NF-kappaB signaling GO:1901222
Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902109
Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process.
2 Q9D1X0 (/IMP) Q9D1X0 (/IMP)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176
Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.
2 O60936 (/IDA) O60936 (/IDA)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176
Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of death-inducing signaling complex assembly GO:1903073
Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of protein targeting to mitochondrion GO:1903215
Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298
Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:1990001
Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process.
2 O60936 (/IDA) O60936 (/IDA)
Inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:1990001
Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
2 O60936 (/IDA) O60936 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q62881 (/IEP)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880
Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
1 Q62881 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q62881 (/TAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q62881 (/IDA)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
1 Q62881 (/IDA)
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
1 Q62881 (/IDA)
Smooth muscle cell proliferation GO:0048659
The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.
1 Q62881 (/IMP)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
1 Q62881 (/IMP)
Negative regulation of mitochondrial calcium ion concentration GO:0051562
Any process that decreases the concentration of calcium ions in mitochondria.
1 Q62881 (/IDA)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q62881 (/IDA)
Inhibition of cysteine-type endopeptidase activity GO:0097340
Any process that prevents the activation of an inactive cysteine-type endopeptidase.
1 Q62881 (/IDA)
Inhibition of cysteine-type endopeptidase activity GO:0097340
Any process that prevents the activation of an inactive cysteine-type endopeptidase.
1 Q62881 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
1 Q62881 (/IMP)
Negative regulation of death-inducing signaling complex assembly GO:1903073
Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly.
1 Q62881 (/IDA)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
1 Q62881 (/IDA)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
1 Q62881 (/IMP)
Negative regulation of protein targeting to mitochondrion GO:1903215
Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion.
1 Q62881 (/IDA)
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298
Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.
1 Q62881 (/IDA)
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q62881 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3 Q62881 (/ISS) Q9D1X0 (/ISS) Q9D1X0 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q62881 (/IDA) Q9D1X0 (/IDA) Q9D1X0 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 O60936 (/TAS) O60936 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O60936 (/ISS) O60936 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O60936 (/TAS) O60936 (/TAS)
Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
2 Q9D1X0 (/IDA) Q9D1X0 (/IDA)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
2 Q9D1X0 (/ISO) Q9D1X0 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q62881 (/IDA)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
1 Q62881 (/IDA)
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