The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Death Domain, Fas
".
FunFam 28: Interleukin 1 receptor-associated kinase 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | Q69FE3 (/IPI) Q69FE3 (/IPI) Q8R4K2 (/IPI) Q9NWZ3 (/IPI) Q9NWZ3 (/IPI) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | Q9NWZ3 (/EXP) Q9NWZ3 (/EXP) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q9NWZ3 (/EXP) Q9NWZ3 (/EXP) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q8R4K2 (/ISO) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q8R4K2 (/ISO) |
|
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
|
1 | Q8R4K2 (/IPI) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
4 | A0A0R4IP49 (/IDA) A0A0R4IQ44 (/IDA) Q6IWL3 (/IDA) Q7ZVW7 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | A0A0R4IP49 (/IDA) A0A0R4IQ44 (/IDA) Q6IWL3 (/IDA) Q7ZVW7 (/IDA) |
|
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Neutrophil mediated immunity GO:0002446
Any process involved in the carrying out of an immune response by a neutrophil.
|
2 | Q9NWZ3 (/IMP) Q9NWZ3 (/IMP) |
|
Neutrophil mediated immunity GO:0002446
Any process involved in the carrying out of an immune response by a neutrophil.
|
2 | Q1RMT8 (/ISS) Q8R4K2 (/ISS) |
|
MyD88-dependent toll-like receptor signaling pathway GO:0002755
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Toll-like receptor 9 signaling pathway GO:0034162
Any series of molecular signals generated as a consequence of binding to toll-like receptor 9.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
2 | Q9NWZ3 (/IMP) Q9NWZ3 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Neutrophil migration GO:1990266
The movement of a neutrophil within or between different tissues and organs of the body.
|
2 | Q9NWZ3 (/IMP) Q9NWZ3 (/IMP) |
|
Neutrophil migration GO:1990266
The movement of a neutrophil within or between different tissues and organs of the body.
|
2 | Q1RMT8 (/ISS) Q8R4K2 (/ISS) |
|
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | Q8R4K2 (/IDA) |
|
Neutrophil mediated immunity GO:0002446
Any process involved in the carrying out of an immune response by a neutrophil.
|
1 | Q8R4K2 (/ISO) |
|
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
1 | D4A7K4 (/IMP) |
|
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
1 | Q8R4K2 (/ISO) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q8R4K2 (/IDA) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | D4A7K4 (/IMP) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q8R4K2 (/ISO) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
1 | Q8R4K2 (/ISO) |
|
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
1 | D4A7K4 (/IMP) |
|
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
1 | Q8R4K2 (/ISO) |
|
Neutrophil migration GO:1990266
The movement of a neutrophil within or between different tissues and organs of the body.
|
1 | Q8R4K2 (/ISO) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
2 | Q9NWZ3 (/TAS) Q9NWZ3 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | D4A7K4 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q8R4K2 (/ISO) |
