The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Unc-5 netrin receptor B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 A0A0R4IE04 (/IPI) A9JR35 (/IPI) B3DJI6 (/IPI) B3DJL0 (/IPI) F1Q711 (/IPI) F1QXJ7 (/IPI) O08722 (/IPI) O08747 (/IPI) O95185 (/IPI) O95185 (/IPI)
(4 more)
Netrin receptor activity involved in chemorepulsion GO:0005043
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin.
4 O95185 (/ISS) O95185 (/ISS) O95185 (/ISS) Q761X5 (/ISS)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
4 O08747 (/IPI) O95185 (/IPI) O95185 (/IPI) O95185 (/IPI)
Netrin receptor activity GO:0005042
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
3 O08721 (/IDA) O08722 (/IDA) O08747 (/IDA)
Netrin receptor activity GO:0005042
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
3 O95185 (/TAS) O95185 (/TAS) O95185 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
3 O95185 (/IPI) O95185 (/IPI) O95185 (/IPI)
Netrin receptor activity GO:0005042
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 Q8K1S3 (/ISO) Q8K1S4 (/ISO)
Netrin receptor activity involved in chemorepulsion GO:0005043
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin.
1 O08747 (/IDA)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 O08747 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O08747 (/ISO)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
6 A0A0R4IE04 (/IMP) A9JR35 (/IMP) B3DJI6 (/IMP) B3DJL0 (/IMP) F1Q711 (/IMP) F1QXJ7 (/IMP)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
6 A0A0R4IE04 (/IMP) A9JR35 (/IMP) B3DJI6 (/IMP) B3DJL0 (/IMP) F1Q711 (/IMP) F1QXJ7 (/IMP)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
6 A0A0R4IE04 (/IMP) A9JR35 (/IMP) B3DJI6 (/IMP) B3DJL0 (/IMP) F1Q711 (/IMP) F1QXJ7 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
4 O95185 (/TAS) O95185 (/TAS) O95185 (/TAS) Q6ZN44 (/TAS)
Chemorepulsion of axon GO:0061643
The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
4 O95185 (/ISS) O95185 (/ISS) O95185 (/ISS) Q761X5 (/ISS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
3 O08721 (/IDA) O08722 (/IDA) O08747 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
3 O08722 (/IGI) O08747 (/IGI) Q8K1S2 (/IGI)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 O95185 (/TAS) O95185 (/TAS) O95185 (/TAS)
Anterior/posterior axon guidance GO:0033564
The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
3 O08747 (/IMP) Q8K1S3 (/IMP) Q8K1S4 (/IMP)
Dorsal root ganglion development GO:1990791
The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
3 O95185 (/IDA) O95185 (/IDA) O95185 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 Q8K1S3 (/ISO) Q8K1S4 (/ISO)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 Q6ZN44 (/ISS) Q8K1S4 (/ISS)
Netrin-activated signaling pathway GO:0038007
A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2 Q6ZN44 (/ISS) Q8K1S4 (/ISS)
Cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742
The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane.
2 Q6UXZ4 (/IDA) Q6UXZ4 (/IDA)
Dorsal root ganglion development GO:1990791
The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
2 O08747 (/ISS) Q761X5 (/ISS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q761X5 (/ISS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 O08747 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 Q8IZJ1 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 Q8K1S3 (/ISO)
Pyramidal neuron differentiation GO:0021859
The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron.
1 Q8K1S2 (/IDA)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 O08747 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O08721 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q8K1S4 (/ISO)
Netrin-activated signaling pathway GO:0038007
A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
1 O08747 (/IGI)
Netrin-activated signaling pathway GO:0038007
A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
1 O08721 (/IMP)
Netrin-activated signaling pathway GO:0038007
A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
1 Q8K1S4 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 O08747 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q8IZJ1 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q8K1S3 (/ISO)
Chemorepulsion of axon GO:0061643
The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
1 O08747 (/IMP)
Cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742
The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane.
1 Q8K1S2 (/ISO)
Dorsal root ganglion development GO:1990791
The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
1 Q7T2Z5 (/IMP)
Dorsal root ganglion development GO:1990791
The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
1 O08747 (/ISO)
Regulation of neuron migration GO:2001222
Any process that modulates the frequency, rate or extent of neuron migration.
1 Q8K1S2 (/IGI)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 Q8IZJ1 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 Q8K1S3 (/ISO)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 O08722 (/IMP)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 Q8K1S3 (/ISO)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 O08721 (/TAS) O08722 (/TAS) O08747 (/TAS) Q6ZN44 (/TAS) Q8K1S3 (/TAS) Q8K1S4 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O08747 (/IDA) O95185 (/IDA) O95185 (/IDA) O95185 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
4 O95185 (/ISS) O95185 (/ISS) O95185 (/ISS) Q761X5 (/ISS)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
4 O95185 (/ISS) O95185 (/ISS) O95185 (/ISS) Q761X5 (/ISS)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
4 O95185 (/ISS) O95185 (/ISS) O95185 (/ISS) Q761X5 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8K1S3 (/TAS) Q8K1S4 (/TAS)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
2 Q6ZN44 (/ISS) Q8K1S4 (/ISS)
Neuron projection membrane GO:0032589
The portion of the plasma membrane surrounding a neuron projection.
2 Q6ZN44 (/ISS) Q8K1S4 (/ISS)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
2 Q6ZN44 (/ISS) Q8K1S4 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O08747 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q761X5 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8K1S2 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 O08747 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 O08747 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 O08747 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q761X5 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 O08747 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q761X5 (/ISS)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 O08747 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 O08721 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q8K1S4 (/ISO)
Neuron projection membrane GO:0032589
The portion of the plasma membrane surrounding a neuron projection.
1 O08721 (/IMP)
Neuron projection membrane GO:0032589
The portion of the plasma membrane surrounding a neuron projection.
1 Q8K1S4 (/ISO)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
1 O08721 (/IMP)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
1 Q8K1S4 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 O08747 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q761X5 (/ISS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 O08722 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q8K1S3 (/ISO)
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