CATH Domain 5z3nA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.370

Domain Context

CATH Clusters

Superfamily	3.30.70.370
Functional Family	DNA polymerase I

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt P19821

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P19821

DPO1_THEAQ

Thermus aquaticus

DNA polymerase I, thermostable

PDB Structure

PDB	5Z3N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Zeng, H., Mondal, M., Song, R., Zhang, J., Xia, B., Liu, M., Zhu, C., He, B., Gao, Y.Q., Yi, C. Angew. Chem. Int. Ed. Engl.