PDB 6brf

PDB Information

PDB6BRF
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
Banerjee, S., Arnst, K.E., Wang, Y., Kumar, G., Deng, S., Yang, L., Li, G.B., Yang, J., White, S.W., Li, W., Miller, D.D.
J. Med. Chem.
HeaderCell Cycle/Inhibitor
Released2017-11-30
Resolution2.500
CATH Insert Date06 Jul, 2018

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 06 Jul, 2018 Chopped
B 06 Jul, 2018 Chopped
C 06 Jul, 2018 Chopped
D 06 Jul, 2018 Chopped
E 06 Jul, 2018 Chopped
F 06 Jul, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
6brfA01 19 Jul, 2018 3.40.50.1440 Assigned
6brfA02 19 Jul, 2018 3.30.1330.20 Assigned
6brfA03 19 Jul, 2018 1.10.287.600 Assigned
6brfB01 19 Jul, 2018 3.40.50.1440 Assigned
6brfB02 19 Jul, 2018 3.30.1330.20 Assigned
6brfB03 19 Jul, 2018 1.10.287.600 Assigned
6brfC01 19 Jul, 2018 3.40.50.1440 Assigned
6brfC02 19 Jul, 2018 3.30.1330.20 Assigned
6brfC03 19 Jul, 2018 1.10.287.600 Assigned
6brfD01 19 Jul, 2018 3.40.50.1440 Assigned
6brfD02 19 Jul, 2018 3.30.1330.20 Assigned
6brfD03 19 Jul, 2018 1.10.287.600 Assigned
6brfE01 19 Jul, 2018 6.10.280.30 Assigned
6brfF01 19 Jul, 2018 3.40.50.11480 Assigned
6brfF02 19 Jul, 2018 3.30.470.20 Assigned
6brfF03 19 Jul, 2018 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q9H169 STMN4_HUMAN Homo sapiens Stathmin-4
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
P02554 TBB_PIG Sus scrofa Tubulin beta chain
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
P02554 TBB_PIG Sus scrofa Tubulin beta chain
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