PDB Information

PDB5E83
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
Oksenberg, D., Dufu, K., Patel, M.P., Chuang, C., Li, Z., Xu, Q., Silva-Garcia, A., Zhou, C., Hutchaleelaha, A., Patskovska, L., Patskovsky, Y., Almo, S.C., Sinha, U., Metcalf, B.W., Archer, D.R.
Br.J.Haematol.
HeaderOxygen Transport
Released2015-10-13
Resolution1.800
CATH Insert Date24 Jul, 2016

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 25 Jul, 2016 Chopped
B 25 Jul, 2016 Chopped
C 25 Jul, 2016 Chopped
D 25 Jul, 2016 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5e83A00 01 Sep, 2016 1.10.490.10 Assigned
5e83B00 01 Sep, 2016 1.10.490.10 Assigned
5e83C00 01 Sep, 2016 1.10.490.10 Assigned
5e83D00 01 Sep, 2016 1.10.490.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P68871 HBB_HUMAN Homo sapiens Hemoglobin subunit beta
P68871 HBB_HUMAN Homo sapiens Hemoglobin subunit beta
P69905 HBA_HUMAN Homo sapiens Hemoglobin subunit alpha
P69905 HBA_HUMAN Homo sapiens Hemoglobin subunit alpha