1 keywords

CATH Domain 5e83A00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.490 Globin-like
Homologous Superfamily 1.10.490.10 Globins

Domain Context

CATH Clusters

Superfamily Globins
Functional Family Hemoglobin subunit alpha

Enzyme Information

UniProtKB Entries (1)

P69905
HBA_HUMAN
Homo sapiens
Hemoglobin subunit alpha

PDB Structure

PDB 5E83
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
Oksenberg, D., Dufu, K., Patel, M.P., Chuang, C., Li, Z., Xu, Q., Silva-Garcia, A., Zhou, C., Hutchaleelaha, A., Patskovska, L., Patskovsky, Y., Almo, S.C., Sinha, U., Metcalf, B.W., Archer, D.R.
Br.J.Haematol.