The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 1260: Sodium channel subunit beta-4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Voltage-gated sodium channel activity GO:0005248
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
6 | Q7M729 (/IDA) Q7M729 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
5 | Q08E08 (/ISS) Q08E08 (/ISS) Q7M729 (/ISS) Q7M729 (/ISS) Q7M730 (/ISS) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
4 | Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
4 | Q8IWT1 (/IPI) Q8IWT1 (/IPI) Q8IWT1 (/IPI) Q8IWT1 (/IPI) |
|
Voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
Voltage-gated sodium channel activity GO:0005248
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
2 | Q7M729 (/IMP) Q7M729 (/IMP) |
|
Voltage-gated sodium channel activity GO:0005248
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
6 | Q7M729 (/IDA) Q7M729 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
|
5 | Q08E08 (/ISS) Q08E08 (/ISS) Q7M729 (/ISS) Q7M729 (/ISS) Q7M730 (/ISS) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
Cardiac muscle cell action potential involved in contraction GO:0086002
An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
Membrane depolarization during cardiac muscle cell action potential GO:0086012
The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
AV node cell action potential GO:0086016
An action potential that occurs in an atrioventricular node cardiac muscle cell.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
|
4 | Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
2 | Q7M729 (/IMP) Q7M729 (/IMP) |
|
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Cardiac muscle cell action potential involved in contraction GO:0086002
An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Membrane depolarization during cardiac muscle cell action potential GO:0086012
The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
AV node cell action potential GO:0086016
An action potential that occurs in an atrioventricular node cardiac muscle cell.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Voltage-gated sodium channel complex GO:0001518
A sodium channel in a cell membrane whose opening is governed by the membrane potential.
|
5 | Q08E08 (/ISS) Q08E08 (/ISS) Q7M729 (/ISS) Q7M729 (/ISS) Q7M730 (/ISS) |
|
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
5 | Q08E08 (/ISS) Q08E08 (/ISS) Q7M729 (/ISS) Q7M729 (/ISS) Q7M730 (/ISS) |
|
Voltage-gated sodium channel complex GO:0001518
A sodium channel in a cell membrane whose opening is governed by the membrane potential.
|
4 | Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Voltage-gated sodium channel complex GO:0001518
A sodium channel in a cell membrane whose opening is governed by the membrane potential.
|
4 | Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) Q8IWT1 (/IMP) |
|
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
|
4 | Q8IWT1 (/ISS) Q8IWT1 (/ISS) Q8IWT1 (/ISS) Q8IWT1 (/ISS) |
|
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
4 | Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) Q8IWT1 (/IDA) |
|
Voltage-gated sodium channel complex GO:0001518
A sodium channel in a cell membrane whose opening is governed by the membrane potential.
|
2 | Q7M729 (/IC) Q7M729 (/IC) |
|
Voltage-gated sodium channel complex GO:0001518
A sodium channel in a cell membrane whose opening is governed by the membrane potential.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
|
2 | Q7M729 (/IDA) Q7M729 (/IDA) |
|
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
2 | Q7M729 (/ISO) Q7M729 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q7M730 (/IDA) |
