The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Pleckstrin homology like domain family B member 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q86SQ0 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q6NSJ2 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 E9QAF4 (/ISO)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q86SQ0 (/HDA)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of gastrulation GO:0010470
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
3 Q86SQ0 (/IMP) Q86UU1 (/IMP) Q86UU1 (/IMP)
Regulation of epithelial to mesenchymal transition GO:0010717
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
3 Q86SQ0 (/IMP) Q86UU1 (/IMP) Q86UU1 (/IMP)
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
3 Q86SQ0 (/IGI) Q86UU1 (/IGI) Q86UU1 (/IGI)
Positive regulation of basement membrane assembly involved in embryonic body morphogenesis GO:1904261
Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis.
3 Q86SQ0 (/IGI) Q86UU1 (/IGI) Q86UU1 (/IGI)
Positive regulation of basement membrane assembly involved in embryonic body morphogenesis GO:1904261
Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis.
3 Q86SQ0 (/IMP) Q86UU1 (/IMP) Q86UU1 (/IMP)
Regulation of gastrulation GO:0010470
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
2 Q6PDH0 (/ISO) Q8K1N2 (/ISO)
Regulation of epithelial to mesenchymal transition GO:0010717
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2 Q6PDH0 (/ISO) Q8K1N2 (/ISO)
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
2 Q6PDH0 (/ISO) Q8K1N2 (/ISO)
Positive regulation of basement membrane assembly involved in embryonic body morphogenesis GO:1904261
Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis.
2 Q6PDH0 (/ISO) Q8K1N2 (/ISO)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q86SQ0 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q8K1N2 (/ISO)
Regulation of gastrulation GO:0010470
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
1 E1C7W8 (/ISS)
Regulation of epithelial to mesenchymal transition GO:0010717
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 E1C7W8 (/ISS)
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
1 Q86SQ0 (/IMP)
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
1 Q8K1N2 (/ISO)
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 Q86SQ0 (/IMP)
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 Q8K1N2 (/ISO)
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
1 Q86SQ0 (/IMP)
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
1 Q8K1N2 (/ISO)
Negative regulation of wound healing, spreading of epidermal cells GO:1903690
Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells.
1 Q86SQ0 (/IMP)
Negative regulation of wound healing, spreading of epidermal cells GO:1903690
Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells.
1 Q8K1N2 (/ISO)
Positive regulation of basement membrane assembly involved in embryonic body morphogenesis GO:1904261
Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis.
1 E1C7W8 (/ISS)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basal cortex GO:0045180
The region that lies just beneath the plasma membrane on the basal edge of a cell.
3 Q86SQ0 (/IDA) Q86UU1 (/IDA) Q86UU1 (/IDA)
Basal cortex GO:0045180
The region that lies just beneath the plasma membrane on the basal edge of a cell.
2 Q6PDH0 (/ISO) Q8K1N2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q86SQ0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8K1N2 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q86SQ0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8K1N2 (/ISO)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q86SQ0 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q8K1N2 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 Q86SQ0 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 Q8K1N2 (/ISO)
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