CATH Domain 5uz0D03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.140	Cytidine Deaminase; domain 2
	3.40.140.20	AICAR transformylase, duplication domain

Domain Context

CATH Clusters

Superfamily	3.40.140.20
Functional Family	Bifunctional purine biosynthesis protein PURH

Enzyme Information

2.1.2.3	Phosphoribosylaminoimidazolecarboxamide formyltransferase. based on mapping to UniProt P31939 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
3.5.4.10	IMP cyclohydrolase. based on mapping to UniProt P31939 IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

PUR9_HUMAN

Homo sapiens

Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB	5UZ0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. Fales, K.R., Njoroge, F.G., Brooks, H.B., Thibodeaux, S., Torrado, A., Si, C., Toth, J.L., Mc Cowan, J.R., Roth, K.D., Thrasher, K.J., Frimpong, K., Lee, M.R., Dally, R.D., Shepherd, T.A., Durham, T.B., Margolis, B.J., Wu, Z., Wang, Y., Atwell, S., Wang, J., Hui, Y.H., Meier, T.I., Konicek, S.A., Geeganage, S. J. Med. Chem.