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1 keywords

CATH Domain 5thpC00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.410 von Willebrand factor, type A domain

Domain Context

CATH Clusters

Superfamily von Willebrand factor, type A domain
Functional Family Integrin, alpha 10

Enzyme Information

UniProtKB Entries (2)

P17301
ITA2_HUMAN
Homo sapiens
Integrin alpha-2
D2YW39
SLEC_CALRH
Calloselasma rhodostoma
Snaclec rhodocetin subunit gamma

PDB Structure

PDB 5THP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dramatic and concerted conformational changes enable rhodocetin to block alpha 2 beta 1 integrin selectively.
Eble, J.A., McDougall, M., Orriss, G.L., Niland, S., Johanningmeier, B., Pohlentz, G., Meier, M., Karrasch, S., Estevao-Costa, M.I., Martins Lima, A., Stetefeld, J.
PLoS Biol.
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