CATH Domain 4cdfC00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.170	Cysteine proteinases. Chain C

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases. Chain C
Functional Family

Enzyme Information

3.4.14.1

Dipeptidyl-peptidase I.

based on mapping to UniProt P53634

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

-!- Also polymerizes dipeptide amides, arylamides and esters at neutral pH. -!- Cl(-)-dependent lysosomal cysteine-type peptidase. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.9.

UniProtKB Entries (1)

P53634

CATC_HUMAN

Homo sapiens

Dipeptidyl peptidase 1

PDB Structure

PDB	4CDF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate. Furber, M., Gardiner, P., Tiden, A.K., Mete, A., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Barber, S., Cage, P., Sanganee, H., Austin, R., Chohan, K., Beri, R., Thong, B., Wallace, A., Oreffo, V., Hutchinson, R., Harper, S., Debreczeni, J., Breed, J., Wissler, L., Edman, K. J.Med.Chem.