CATH Domain 3ut2B02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.420	Peroxidase; domain 2
	1.10.420.10	Peroxidase, domain 2

Domain Context

CATH Clusters

Superfamily	Peroxidase, domain 2
Functional Family

Enzyme Information

1.11.1.21

Catalase peroxidase.

based on mapping to UniProt A4QUT2

(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.

-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

A4QUT2

KATG2_MAGO7

Pyricularia oryzae 70-15

Catalase-peroxidase 2

PDB Structure

PDB	3UT2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases: ANSWERS FROM FIRST CRYSTAL STRUCTURE AND UNFOLDING STUDIES. Zamocky, M., Garcia-Fernandez, Q., Gasselhuber, B., Jakopitsch, C., Furtmuller, P.G., Loewen, P.C., Fita, I., Obinger, C., Carpena, X. J.Biol.Chem.

Network disruptions