CATH Domain 3rilC01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family	Lysosomal acid glucosylceramidase

Enzyme Information

2.4.1.-	Hexosyltransferases. based on mapping to UniProt P04062
3.2.1.104	Steryl-beta-glucosidase. based on mapping to UniProt P04062 Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol. -!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
3.2.1.45	Glucosylceramidase. based on mapping to UniProt P04062 D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine. -!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).

UniProtKB Entries (1)

GLCM_HUMAN

Homo sapiens

Lysosomal acid glucosylceramidase

PDB Structure

PDB	3RIL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Orwig, S.D., Tan, Y.L., Grimster, N.P., Yu, Z., Powers, E.T., Kelly, J.W., Lieberman, R.L. Biochemistry