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1 keywords

CATH Domain 3itmB00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt O00408
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

UniProtKB Entries (1)

O00408
PDE2A_HUMAN
Homo sapiens
CGMP-dependent 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 3ITM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.
Pandit, J., Forman, M.D., Fennell, K.F., Dillman, K.S., Menniti, F.S.
Proc.Natl.Acad.Sci.USA
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