CATH Domain 3it4B01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.2330	arginine biosynthesis bifunctional protein fold
	3.30.2330.10	arginine biosynthesis bifunctional protein suprefamily

Domain Context

CATH Clusters

Superfamily	arginine biosynthesis bifunctional protein suprefamily
Functional Family	Arginine biosynthesis bifunctional protein ArgJ

Enzyme Information

2.3.1.1	Amino-acid N-acetyltransferase. based on mapping to UniProt P9WPZ3 Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. -!- Also acts with L-aspartate and, more slowly, with some other amino acids.
2.3.1.35	Glutamate N-acetyltransferase. based on mapping to UniProt P9WPZ3 N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L- glutamate. -!- Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity.

UniProtKB Entries (1)

ARGJ_MYCTU

Mycobacterium tuberculosis H37Rv

Arginine biosynthesis bifunctional protein ArgJ

PDB Structure

PDB	3IT4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor. Sankaranarayanan, R., Cherney, M.M., Garen, C., Garen, G., Niu, C., Yuan, M., James, M.N. J.Mol.Biol.