CATH Domain 2zyaB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44

Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).

based on mapping to UniProt P00350

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P00350

6PGD_ECOLI

Escherichia coli K-12

6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB	2ZYA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism Chen, Y.-Y., Ko, T.-P., Chen, W.-H., Lo, L.-P., Lin, C.-H., Wang, A.H.-J. J.Struct.Biol.

Network disruptions