CATH Domain 2zevB00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Geranylgeranyl pyrophosphate synthase

Enzyme Information

2.5.1.-	Transferring alkyl or aryl groups, other than methyl groups. based on mapping to UniProt Q12051
2.5.1.10	(2E,6E)-farnesyl diphosphate synthase. based on mapping to UniProt Q12051 Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate. -!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.
2.5.1.29	Geranylgeranyl diphosphate synthase. based on mapping to UniProt Q12051 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. -!- Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
2.5.1.1	Dimethylallyltranstransferase. based on mapping to UniProt Q12051 Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. -!- Will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

GGPPS_YEAST

Saccharomyces cerevisiae S288C

Geranylgeranyl pyrophosphate synthase

PDB Structure

PDB	2ZEV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation Zhang, Y., Cao, R., Yin, F., Hudock, M.P., Guo, R.T., Krysiak, K., Mukherjee, S., Gao, Y.-G., Robinson, H., Song, Y., No, J.H., Bergan, K., Leon, A., Cass, L., Goddard, A., Chang, T.-K., Lin, F.-Y., Van Beek, E., Papapoulos, S., Wang, A.H.-J., Kubo, T., Ochi, M., Mukkamala, D., Oldfield, E. J.Am.Chem.Soc.