CATH Domain 2f1fB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.260	ACT domain

Domain Context

CATH Clusters

Superfamily	3.30.70.260
Functional Family	Acetolactate synthase, small subunit

Enzyme Information

2.2.1.6

Acetolactate synthase.

based on mapping to UniProt P00894

2 pyruvate = 2-acetolactate + CO(2).

-!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18.

UniProtKB Entries (1)

P00894

ILVH_ECOLI

Escherichia coli K-12

Acetolactate synthase isozyme 3 small subunit

PDB Structure

PDB	2F1F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of the Regulatory Subunit of Acetohydroxyacid Synthase Isozyme III from Escherichia coli. Kaplun, A., Vyazmensky, M., Zherdev, Y., Belenky, I., Slutzker, A., Mendel, S., Barak, Z., Chipman, D.M., Shaanan, B. J.Mol.Biol.