×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Domain Context

CATH Clusters

Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Functional Family

Enzyme Information

1.1.1.88
Hydroxymethylglutaryl-CoA reductase.
based on mapping to UniProt P13702
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.

UniProtKB Entries (1)

P13702
MVAA_PSEMV
Pseudomonas mevalonii
3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB Structure

PDB 1T02
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.
Tabernero, L., Rodwell, V.W., Stauffacher, C.V.
J.Biol.Chem.
CATH-Gene3D is a Global Biodata Core Resource Learn more...