CATH Domain 1i9tA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	mRNA-capping enzyme

Enzyme Information

2.7.7.50	mRNA guanylyltransferase. based on mapping to UniProt O55236 GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA. -!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.
3.1.3.33	Polynucleotide 5'-phosphatase. based on mapping to UniProt O55236 A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate. -!- Does not act on nucleoside monophosphates. -!- Induced in Escherichia coli by T-even phages.

UniProtKB Entries (1)

MCE1_MOUSE

Mus musculus

MRNA-capping enzyme

PDB Structure

PDB	1I9T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. Changela, A., Ho, C.K., Martins, A., Shuman, S., Mondragon, A. EMBO J.