CATH Domain 1b0aA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10860	Leucine Dehydrogenase, chain A, domain 1

Domain Context

CATH Clusters

Superfamily	Leucine Dehydrogenase, chain A, domain 1
Functional Family

Enzyme Information

1.5.1.5	Methylenetetrahydrofolate dehydrogenase (NADP(+)). based on mapping to UniProt P24186 5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
3.5.4.9	Methenyltetrahydrofolate cyclohydrolase. based on mapping to UniProt P24186 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.

UniProtKB Entries (1)

FOLD_ECOLI

Escherichia coli K-12

Bifunctional protein FolD

PDB Structure

PDB	1B0A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase. Shen, B.W., Dyer, D.H., Huang, J.Y., D'Ari, L., Rabinowitz, J., Stoddard, B.L. Protein Sci.